Characterization of Campylobacter cinaedi and C. fennelliae antigens and analysis of the human immune response.
Characterization of Campylobacter cinaedi and C. fennelliae antigens and analysis of the human immune response.
复制标题
弯曲杆菌和芬氏弯曲杆菌抗原的表征以及人体免疫反应的分析。
DOI：
10.1093/infdis/159.4.635
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Stamm,WE
中科院分区：
文献类型：
--
作者：
Flores,BM;Fennell,CL;Stamm,WE
弯曲菌、Cinaedii和C.经SDS-PAGE鉴定，Jennlobus与其他5种过氧化氢酶阳性弯曲杆菌不同。用兔抗血清进行免疫印迹，C . cinaediandC. Jennellia的抗原谱具有高度的种特异性，与其他弯曲杆菌属种的抗原几乎没有交叉反应性。13例男同性恋者C.感染表明与五种抗原（96-41 kDa）的反应一致。所有检测的人血清，包括10个培养阴性的人血清，都与C. cinaedi 59-和64-kDa条带，但感染个体的总体反应要强得多。C. cinaediandC. fennellia可以用来区分这些物种从其他弯曲杆菌物种。至少六个C。Cinaediantigens在人类中是免疫原性的。
Whole-cell protein patterns ofCampylobacte, cinaediandC . jennelliae,identified by SDS-PAGE, differed from one another and from five other catalase-positiveCampylobacterspecies. When immunoblotted with rabbit antisera,C . cinaediandC. jennelliaeshowed antigenic profiles that were highly species-specific and had little or no cross-reactivity with antigens of the otherCampylobacterspecies tested. Antibody responses of 13 homosexual men withC . cinaediinfection demonstrated consistent reactions with five antigens (96–41 kDa). All human sera tested, including those of 10 culture-negative individuals, reacted with theC. cinaedi59- and 64-kDa bands, but the overall responses of infected individuals were much stronger. The antigenic profiles ofC. cinaediandC. fennelliaecan be used to distinguish these species from otherCampylobacterspecies. At least sixC. cinaediantigens are immunogenic in humans.