Prevalence of hepatitis B in the southeast of China: a population-based study with a large sample size
Prevalence of hepatitis B in the southeast of China: a population-based study with a large sample size
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DOI：
10.1097/meg.0b013e328347322b
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发表时间：
2011-08-01
影响因子：
2.1
通讯作者：
Ruan, Bing
中科院分区：
文献类型：
--
作者：
Luo, Zhuanbo;Xie, Yirui;Ruan, Bing
目的 乙型肝炎是中国的一个重大公共卫生问题。然而，在过去 10 年中，对乙型肝炎病毒 (HBV) 患病率的估计很少，结果并不总是一致。本研究的目的是调查成人 HBV 的流行病学，并为健康规划和监测提供最新的基线数据。 方法 在基于社区的、横断面的、按年龄分层的成人样本（20 岁或以上）中确定 HBV 的患病率。研究人群是通过随机多阶段整群抽样来选择的。获得19 933名参与者的人口统计信息和血清学样本。结果抗HBV核心抗体、HBV表面抗原(HBsAg)和抗HBV表面抗体的患病率分别为38.6%、7.9%和44.9%。我们发现男性和女性之间乙型肝炎感染存在统计学显着差异（P < 0.001）。乙型肝炎病毒感染率随着年龄的增长而增加。海岛人群的 HBsAg 阳性率和 HBV 感染率高于平原地区人群。 15.7% 和 7.2% 的 HBsAg 阳性和 HBsAg 阴性患者的丙氨酸氨基转移酶水平升高（≥ 38 IU/l）；丙氨酸氨基转移酶升高的比例男性（12.7%）明显高于女性（4.7%）（P < 0.001）。 30岁以上HBsAg阳性人群甲胎蛋白阳性率为2%。结论浙北地区成人存在中、高流行区。过去 20 年来，疫苗接种计划为减少感染做出了贡献，但仍需进一步努力将该地区转变为“低流行”地区。 Eur J Gastroenterol Hepatol 23：695-700 (C) 2011 Wolters Kluwer Health |利平科特·威廉姆斯和威尔金斯。
Objective Hepatitis B is a major public health problem in China. However, in the past 10 years, estimates of the prevalence of hepatitis B virus (HBV) have been sparse, with results that do not always agree. The purpose of this study was to investigate the epidemiology of HBV in adults and to provide the most recent baseline data for planning and monitoring of health.Methods The prevalence of HBV was determined in a community-based, cross-sectional, age-stratified sample of adults (aged 20 years or older). The study population was selected using random multistage cluster sampling. Demographic information and serological samples were obtained from 19 933 participants.Results The prevalence of anti-HBV core antibody, HBV surface antigen (HBsAg), and anti-HBV surface antibody was 38.6, 7.9, and 44.9%, respectively. We found statistically significant differences in hepatitis B infection between men and women (P < 0.001). The prevalence of HBV infection increased with age. The rates of HBsAg positivity and HBV infection in individuals living on an island were higher than those of individuals living in plains. The alanine aminotransferase level was elevated (>= 38 IU/l) in 15.7 and 7.2% of HBsAg-positive and HBsAg-negative patients; the proportion of elevated alanine aminotransferase was markedly higher in men (12.7%) than in women (4.7%) (P < 0.001). The alpha-fetoprotein-positive rate was 2% in HBsAg-positive individuals who were aged 30 years or older.Conclusion Borderline intermediate/high endemicity was found among adults in the northern region of Zhejiang Province. The vaccination program has contributed to a reduction in infection over the last 20 years, although further efforts are required to turn the region into a 'low-endemicity' area. Eur J Gastroenterol Hepatol 23: 695-700 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.