Acute exercise decreases vaccine reactions following influenza vaccination among older adults
Acute exercise decreases vaccine reactions following influenza vaccination among older adults
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DOI：
10.1016/j.bbih.2019.100009
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Edwards, Kate M.
中科院分区：
文献类型：
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作者：
Bohn-Goldbaum, Erika;Pascoe, April;Edwards, Kate M.
尽管流感疫苗接种对于减轻疾病负担有价值且有效，但其有效性较低，尤其是对于高危人群。研究表明，剧烈运动可以改善疫苗反应，尤其是对于较弱的抗原。在这里，我们研究了抵抗运动对健康老年人流感疫苗接种的急性和长期反应的影响。 46 名参与者（47.8% 为男性，平均年龄 73.4 & PLUSMN；6.6 岁）被随机分配进行一次 45 分钟的中等强度抵抗运动，或者在接种流感疫苗之前安静地坐着。在六个月的随访期间，急性运动减少了疫苗反应，但对抗体反应或流感样症状的发展没有影响。检查心理社会和行为特征与疫苗接种反应的潜在关联。与前一年未接种疫苗的参与者相比，前一年接种疫苗的参与者 (n = 36) 基线抗体滴度较高，但随访滴度没有变化，也没有在 6 个月内更频繁地出现流感样症状。这些发现为急性运动减少疫苗反应的能力提供了进一步的支持，并为未来探索疫苗反应的危险因素提出了建议。
Although valuable and effective in decreasing disease burden, influenza vaccination has low rates of efficacy, especially in those at most risk. Studies have shown that acute exercise can improve vaccine responses, most consistently with weaker antigens. Here we examined the effect of resistance exercise on the acute and longer -term responses to influenza vaccination among healthy older adults. Forty-six participants (47.8% male, mean 73.4 & PLUSMN; 6.6 years) were randomised to perform one 45-min moderate-intensity resistance exercise session or sit quietly prior to the receipt of influenza vaccination.Acute exercise reduced vaccine reactions but had no effect on either antibody responses or development of influenza-like symptoms during six months of follow-up. Psychosocial and behavioural characteristics were examined for potential associations with the responses to vaccination. Participants (n = 36) vaccinated in the previous year had higher baseline antibody titres but not follow-up titres nor more frequent experience of influenza-like symptoms over 6 months compared to those unvaccinated in the previous year. These findings provide further support for the ability of acute exercise to reduce vaccine reactions and suggest risk factors for vaccine responses for future exploration.