Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance
Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance
复制标题
DOI：
--
复制
发表时间：
2021
影响因子：
7
通讯作者：
Mao Xinzhan
中科院分区：
文献类型：
--
作者：
Xie Peng;Wang Yushu;Wei Dengshuai;Zhang Lingpu;Zhang Bin;Xiao Haihua;Song Haiqin;Mao Xinzhan
Platinum drugs are commonly used in cancer therapy, but their therapeutic outcomes have been significantly compromised by the drug resistance of cancer cells. To this end, intensive efforts have been made to develop nanoparticle-based drug delivery systems for platinum drugs, due to their multifunctionality in delivering drugs, in modulating the tumor microenvironment, and in integrating additional genes, proteins, and small molecules to overcome chemoresistance in cancers. To facilitate the clinical application of these promising nanoparticle-based platinum drug delivery systems, this paper summarizes the common mechanisms for chemoresistance towards platinum drugs, the advantages of nanoparticles in drug delivery, and recent strategies of nanoparticle-based platinum drug delivery. Furthermore, we discuss how to design delivery platforms more effectively to overcome chemoresistance in cancers, thereby improving the efficacy of platinum-based chemotherapy..
