Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome.
Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome.
复制标题
DOI：
10.1128/msphere.00056-15
复制
发表时间：
2016-05
期刊：
影响因子：
4.8
通讯作者：
Parsonnet J
中科院分区：
文献类型：
--
作者：
Poole AC;Pischel L;Ley C;Suh G;Goodrich JK;Haggerty TD;Ley RE;Parsonnet J
三氯生和三氯卡班是牙膏和肥皂中常用的商业杀微生物剂。目前尚不清楚这些化学物质对人体微生物组或内分泌功能有什么影响。从这项随机交叉研究中，似乎三氯生和三氯卡班的常规个人护理使用既不会对肠道和口腔中的微生物群落产生重大影响，也不会改变人体内分泌功能的标志物。众所周知，常用的抗生素会改变人体微生物群。我们假设，三氯生和三氯卡班，许多家庭和个人护理产品（HPCP）的成分，可能会改变口腔和肠道微生物群，对代谢功能和体重产生潜在影响。在一项双盲、随机、交叉研究中，受试者接受含三氯生和三氯卡班（TCS）或不含三氯生/三氯卡班（nTCS）的HPCP 4个月，然后再换用其他产品4个月。在基线和整个研究期间定期采集血液、粪便、牙龈菌斑和尿液样本以及体重数据。分析血液样本中的代谢和内分泌标志物，并分析尿液样本中的三氯生。然后分析粪便和口腔样本中的微生物组。尽管TCS和nTCS阶段之间尿液中三氯生的含量存在显著差异，但在微生物组组成、代谢或内分泌标志物或体重方面没有发现差异。尽管这项研究受到样本量小和HPCP给药不精确的限制，但暴露于HPCP的生理水平的三氯生似乎对人类口腔或肠道微生物组结构或一组代谢标志物没有显著或重要的影响。重要性三氯生和三氯卡班是牙膏和肥皂中常用的商业杀微生物剂。目前尚不清楚这些化学物质对人体微生物组或内分泌功能有什么影响。从这项随机交叉研究中，似乎三氯生和三氯卡班的常规个人护理使用既不会对肠道和口腔中的微生物群落产生重大影响，也不会改变人体内分泌功能的标志物。
Triclosan and triclocarban are commonly used commercial microbicides found in toothpastes and soaps. It is unknown what effects these chemicals have on the human microbiome or on endocrine function. From this randomized crossover study, it appears that routine personal care use of triclosan and triclocarban neither exerts a major influence on microbial communities in the gut and mouth nor alters markers of endocrine function in humans. Commonly prescribed antibiotics are known to alter human microbiota. We hypothesized that triclosan and triclocarban, components of many household and personal care products (HPCPs), may alter the oral and gut microbiota, with potential consequences for metabolic function and weight. In a double-blind, randomized, crossover study, participants were given triclosan- and triclocarban (TCS)-containing or non-triclosan/triclocarban (nTCS)-containing HPCPs for 4 months and then switched to the other products for an additional 4 months. Blood, stool, gingival plaque, and urine samples and weight data were obtained at baseline and at regular intervals throughout the study period. Blood samples were analyzed for metabolic and endocrine markers and urine samples for triclosan. The microbiome in stool and oral samples was then analyzed. Although there was a significant difference in the amount of triclosan in the urine between the TCS and nTCS phases, no differences were found in microbiome composition, metabolic or endocrine markers, or weight. Though this study was limited by the small sample size and imprecise administration of HPCPs, triclosan at physiologic levels from exposure to HPCPs does not appear to have a significant or important impact on human oral or gut microbiome structure or on a panel of metabolic markers. IMPORTANCE Triclosan and triclocarban are commonly used commercial microbicides found in toothpastes and soaps. It is unknown what effects these chemicals have on the human microbiome or on endocrine function. From this randomized crossover study, it appears that routine personal care use of triclosan and triclocarban neither exerts a major influence on microbial communities in the gut and mouth nor alters markers of endocrine function in humans.