Hospitalizations for varicella in the United States, 1988 to 1999
Hospitalizations for varicella in the United States, 1988 to 1999
复制标题
DOI：
10.1097/00006454-200210000-00009
复制
发表时间：
2002-10-01
影响因子：
3.6
通讯作者：
Seward, J
中科院分区：
文献类型：
--
作者：
Galil, K;Brown, C;Seward, J
背景资料。随着水痘疫苗使用量的增加，水痘流行病学也在发生变化。为了描述疫苗引入前后严重水痘疾病的流行病学，分析了1988至1999年全国医院出院调查(NHDS)的数据。排除了因不同适应症而住院的水痘偶发病例。在预防接种时代(1988至1995年)，每年有10632人因水痘住院。最常见的并发症是病毒性肺炎(20.9%)、水/电解质紊乱(19.3%)和软组织感染(17.8%)。大多数人(89.1%)没有严重的潜在免疫损害情况。平均住院天数为5.4天，相当于每年57000天的住院天数。在获得疫苗许可证后的第一年(1996年至1999年)，疫苗覆盖率达到59%。虽然在统计学上没有统计学意义，但有减少住院次数和平均住院时间的趋势。水痘发病率在预防接种时代比以前报道的要高。尽管没有明显的下降，但在疫苗接种后的第一年，住院人数出现了减少的趋势。
Background. Varicella epidemiology is changing with increasing use of the varicella vaccine.Methods. To describe the epidemiology of severe varicella disease before and after vaccine introduction, data from the National Hospital Discharge Survey (NHDS) for 1988 to 1999 were analyzed. Incidental cases of varicella in persons hospitalized for a different indication were excluded.Results. In the prevaccination era (1988 to 1995), there were 10 632 varicella hospitalizations annually. The most common complications were viral pneumonitis (20.9%), fluid/electrolyte disturbances (19.3%) and soft tissue infections (17.8%). Most (89.1%) persons had no severe underlying immunocompromising conditions. The mean length of hospitalization was 5.4 days, corresponding to similar to57000 days of hospitalization annually. In the first years after vaccine licensure (1996 to 1999), vaccine coverage reached 59%. Although not statistically significant, there was a trend toward decreased hospitalizations and a decline in mean length of hospitalization.Conclusions. Varicella morbidity was higher in the prevaccination era than previously reported. Although no significant decline is evident, a trend toward decreased hospitalizations is emerging in the first years after vaccine introduction.