Fluorine-18-FDG PET imaging is negative in bronchioloalveolar lung carcinoma.
Fluorine-18-FDG PET imaging is negative in bronchioloalveolar lung carcinoma.
复制标题
细支气管肺泡肺癌的 Fluorine-18-FDG PET 成像呈阴性。
DOI：
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发表时间：
1998
影响因子：
9.3
通讯作者：
I. Yamamoto
中科院分区：
文献类型：
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作者：
K. Higashi;Y. Ueda;H. Seki;Kokichi Yuasa;M. Oguchi;Tetsuhiko Noguchi;M. Taniguchi;H. Tonami;T. Okimura;I. Yamamoto
未标记
我们的研究目的是建立PET的准确性与18氟-脱氧葡萄糖（FDG）发现局部形成细支气管肺泡肺癌（BAC），并探讨FDG摄取和细胞分化程度之间的相关性在肺腺癌。
材料
29例患者30例肺腺癌（7例细支气管肺泡癌，9例高分化，2例高-中分化，11例中分化和1例低分化）进行了研究。所有患者均在FDG PET研究后4周内接受开胸手术。对于定性分析，使用五点分级系统对肿瘤中FDG活性的程度进行视觉评分：0 =与背景活性相同，1 =小于纵隔血池活性，2 =与纵隔血池活性相同，3 =略大于纵隔血池活性，4 =显著大于纵隔血池活性。2-4级活动灶被认为是肿瘤。对于半定量分析，计算标准化摄取值（SUV）。
结果
在7例BAC中，4个病灶（57%）在FDG PET上显示阴性结果，而在23例非BAC中，仅1个病灶（4%）显示阴性结果，这是一个高分化腺癌。BAC的平均视觉评分（1.43 ± 1.27）显著低于非BAC（3.17 ± 1.03）（p = 0.001）。BAC的平均SUV（1.36 +/- 0.821）显著低于高分化腺癌（2.92 +/- 1.28）（p = 0.014）;高分化腺癌的平均SUV显著低于中度分化腺癌（4.63 +/- 1.86）（p = 0.031）。这三种组织学类型之间的平均大小无显著差异。
结论
肺腺癌的FDG摄取与细胞分化程度相关。FDG PET可能显示BAC阴性结果。
UNLABELLED
The goals of our study were to establish PET accuracy with 18F-fluorodeoxyglucose (FDG) in finding localized formations of bronchioloalveolar lung carcinoma (BAC) and to investigate the correlation between FDG uptake and the degree of cell differentiation in adenocarcinoma of the lung.
MATERIALS
Twenty-nine patients with 30 adenocarcinomas of the lung (7 bronchioloalveolar lung carcinomas, 9 well differentiated, 2 well-moderately differentiated, 11 moderately differentiated and 1 poorly differentiated) were studied. All patients underwent thoracotomies within 4 wk after the FDG PET study. For qualitative analysis, the degree of FDG activity in the tumors was visually scored using a five-point grading system: 0 = same to background activity, 1 = less than mediastinal blood-pool activity, 2 = same to mediastinal blood-pool activity, 3 = slightly greater than mediastinal blood-pool activity and 4 = substantially greater than mediastinal blood-pool activity. Foci of activity with Grades 2-4 were considered tumors. For semiquantitative analysis, standardized uptake values (SUV) were calculated.
RESULTS
In 7 BACs, 4 lesions (57%) showed negative results on FDG PET, while in 23 non-BACs, only 1 lesion (4%), which was a well-differentiated adenocarcinoma showed a negative result. BACs' mean visual score (1.43 +/- 1.27) was significantly lower than that of non-BACs (3.17 +/- 1.03) (p = 0.001). The BACs' mean SUV (1.36 +/- 0.821) was significantly lower than that of well-differentiated adenocarcinomas (2.92 +/- 1.28) (p = 0.014); the mean SUV of well-differentiated adenocarcinomas was significantly lower than that of moderately differentiated adenocarcinomas (4.63 +/- 1.86) (p = 0.031). No significant differences were apparent in average size among these three histologic types.
CONCLUSION
A correlation was observed between FDG uptake and the degree of cell differentiation in adenocarcinoma of the lung. FDG PET may show negative results for BAC.