Spiral Perfusion Imaging With Consecutive Echoes (SPICE™) for the Simultaneous Mapping of DSC- and DCE-MRI Parameters in Brain Tumor Patients: Theory and Initial Feasibility.
Spiral Perfusion Imaging With Consecutive Echoes (SPICE™) for the Simultaneous Mapping of DSC- and DCE-MRI Parameters in Brain Tumor Patients: Theory and Initial Feasibility.
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DOI：
10.18383/j.tom.2016.00217
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Schmainda KM
中科院分区：
文献类型：
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作者：
Paulson ES;Prah DE;Schmainda KM
动态对比增强（DCE）和动态磁化率对比（DSC）磁共振成像（MRI）是最常用于探测脑肿瘤血管生成特征的灌注成像技术。通过这些方法，T1和T2/T2* 加权成像序列用于成像钆（Gd）基造影剂的分布。然而，众所周知，Gd在组织中表现出T1、T2和T2* 缩短效应，因此，DCE和DSC-MRI的结果可能会受到这些相反效应的混淆。特别是，剩余磁化率效应与T1缩短竞争，这可能混淆DCE-MRI参数，而偶极T1和T2泄漏和剩余磁化率效应可能混淆DSC-MRI参数。我们在这里介绍一种新的灌注成像采集和后处理方法，称为螺旋灌注成像与连续回波（SPICE），可用于同时采集DCE和DSC-MRI数据，这只需要一个单一的剂量的Gd造影剂，不需要收集一个precontrast T1地图的DCE-MRI处理，并消除了混淆造影剂的影响，由于造影剂外渗。这里沿着提供了SPICE的详细数学描述，并演示了其在高级别胶质瘤患者中的实用性。
Dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are the perfusion imaging techniques most frequently used to probe the angiogenic character of brain neoplasms. With these methods, T1- and T2/T2*-weighted imaging sequences are used to image the distribution of gadolinium (Gd)-based contrast agents. However, it is well known that Gd exhibits combined T1, T2, and T2* shortening effects in tissue, and therefore, the results of both DCE- and DSC-MRI can be confounded by these opposing effects. In particular, residual susceptibility effects compete with T1 shortening, which can confound DCE-MRI parameters, whereas dipolar T1 and T2 leakage and residual susceptibility effects can confound DSC-MRI parameters. We introduce here a novel perfusion imaging acquisition and postprocessing method termed Spiral Perfusion Imaging with Consecutive Echoes (SPICE) that can be used to simultaneously acquire DCE- and DSC-MRI data, which requires only a single dose of the Gd contrast agent, does not require the collection of a precontrast T1 map for DCE-MRI processing, and eliminates the confounding contrast agent effects due to contrast extravasation. A detailed mathematical description of SPICE is provided here along with a demonstration of its utility in patients with high-grade glioma.