EFFECTS OF ANESTHESIA ON CARDIAC AND RENAL SYMPATHETIC-NERVE ACTIVITIES AND PLASMA-CATECHOLAMINES
EFFECTS OF ANESTHESIA ON CARDIAC AND RENAL SYMPATHETIC-NERVE ACTIVITIES AND PLASMA-CATECHOLAMINES
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DOI：
10.1152/ajpregu.1993.265.4.r792
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发表时间：
1993-10-01
影响因子：
--
通讯作者：
NISHIURA, N
中科院分区：
文献类型：
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作者：
MATSUKAWA, K;NINOMIYA, I;NISHIURA, N
用清醒猫观察了戊巴比妥和氯醛糖对心交感神经活动（CSNA）、肾交感神经活动（RSNA）、动脉压（AP）和心率（HR）的影响。间歇性采集动脉血以测量血浆肾上腺素。戊巴比妥（25-30 mg/kg iv）可降低CSNA、RSNA、AP和HR。CSNA（71 +/- 7%）的降低幅度大于RSNA（33 +/- 12%），且持续时间更长。氯醛糖（40-50 mg/kg iv）使CSNA和HR降低66 +/- 9%，使RSNA增加127 +/-122%，但不影响AP。通过将AP增加到145 mmHg和将AP降低到55 mmHg来检查AP和CSNA之间的压力感受性反射关系。戊巴比妥和氯醛糖都使AP-CSNA关系曲线向下移动，并使曲线的斜率变钝，表明这两种药物都能减弱紧张性和压力反射性心脏交感神经流出。戊巴比妥和氯醛糖降低血浆肾上腺素，表明肾上腺交感神经活动减少。它的结论是，戊巴比妥或氯醛糖影响差异交感神经流出到不同的器官，如心脏，肾脏和肾上腺。
The effects of pentobarbital and chloralose on cardiac sympathetic nerve activity (CSNA), renal sympathetic nerve activity (RSNA), arterial pressure (AP), and heart rate (HR) were examined using conscious cats. Arterial blood was sampled intermittently to measure plasma epinephrine. Pentobarbital (25-30 mg/kg iv) decreased CSNA, RSNA, AP, and HR. The reduction of CSNA (71 +/- 7%) was larger and lasted longer than that of RSNA (33 +/- 12%). Chloralose (40-50 mg/kg iv) decreased CSNA 66 +/- 9% and HR, increased RSNA 127 +/- 122%, and did not affect AP. The baroreflex relationship between AP and CSNA was examined by increasing AP to 145 mmHg and decreasing AP to 55 mmHg. Both pentobarbital and chloralose shifted the AP-CSNA relationship curve downward and blunted the slope of the curve, indicating that both drugs attenuate tonic and baroreflex cardiac sympathetic outflow. Pentobarbital and chloralose reduced plasma epinephrine, suggesting a decrease in adrenal sympathetic nerve activity. It is concluded that pentobarbital or chloralose affects differentially sympathetic outflows to different organs such as the heart, kidney, and adrenal gland.