VIRULENCE RANKING OF SOME MYCOBACTERIUM-TUBERCULOSIS AND MYCOBACTERIUM-BOVIS STRAINS ACCORDING TO THEIR ABILITY TO MULTIPLY IN THE LUNGS, INDUCE LUNG PATHOLOGY, AND CAUSE MORTALITY IN MICE
VIRULENCE RANKING OF SOME MYCOBACTERIUM-TUBERCULOSIS AND MYCOBACTERIUM-BOVIS STRAINS ACCORDING TO THEIR ABILITY TO MULTIPLY IN THE LUNGS, INDUCE LUNG PATHOLOGY, AND CAUSE MORTALITY IN MICE
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DOI：
10.1128/iai.63.9.3428-3437.1995
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发表时间：
1995-09-01
影响因子：
3.1
通讯作者：
NORTH, RJ
中科院分区：
文献类型：
--
作者：
DUNN, PL;NORTH, RJ
三株结核分枝杆菌强毒株（H37 Rv，Erdman和NYH-27）和牛支原体的两个强毒株（Ravenel和分支）系列在它们在小鼠肝脏和肺中的生长速率、它们引起肺病理学的能力以及它们引起死亡所需的时间方面进行了比较。所有菌株引起的感染进展20天或更长时间，然后在肝脏中消退，但在肺中不消退。在肺中，感染持续并诱导进行性病理学。根据宿主存活时间，Ravenel是最毒力的菌株，其次，按毒力降序排列为分支、H37 Rv、Erdman和NYH-27。感染结核分枝杆菌菌株的小鼠的更长的存活时间允许肺组织病理学从组织细胞性肺泡炎改变为慢性成纤维细胞性纤维化的时间，其最终消除了大部分肺结构。相比之下，在感染牛分枝杆菌菌株的小鼠中，在早期感染期间发展的肺泡炎迅速且广泛，足以在慢性肺病理学变得明显之前导致死亡。在CD 4（+）T细胞耗竭的小鼠中，所有强毒株的生长增加诱导坏死性渗出性肺损伤，其使大部分肺泡囊迅速充满炎性细胞，这些小鼠比感染的对照小鼠死亡更早，减毒毒株在体内具有更长的群体倍增时间，并且在免疫活性小鼠的肺或肝脏中不引起进行性疾病或病理学。
Three virulent strains of Myobacterium tuberculosis (H37Rv, Erdman, and NYH-27) and two virulent strains of M, bovis (Ravenel and Branch) sere compared in terms of their growth rates in the livers and the lungs of mice, their ability to cause lung pathology, and the time taken for them to cause death, In immunocompetent mice, all strains caused an infection that progressed for 20 days or more and then underwent resolution in the liver but not in the lungs, In the lungs, infection persisted and induced progressive pathology, According to host survival time, Ravenel was the most virulent strain, followed, in decreasing order of virulence, by Branch, H37Rv, Erdman, and NYH-27. The much longer survival times of mice infected with M, tuberculosis strains allowed time for lung histopathology to change from a histiocytic alveolitis to a chronic fibroblastic fibrosis that eventually obliterated most of the lung architecture, By contrast, in mice infected with M, bovis strains, the alveolitis that developed during early infection was rapid and expansive enough to cause death before chronic lung pathology became evident, In mice depleted of CD4(+) T cells, increased growth of all virulent strains induced necrotic exudative lung lesions that rapidly filled most of the alveolar sacs with inflammatory cells, These mice died much earlier than infected control mice did, Attenuated strains had longer population doubling times in vivo and failed to cause progressive disease or pathology in the lungs or fivers of immunocompetent mice.