Area postrema lesions in rats appear to disrupt rapid feedback inhibition of fluid intake
Area postrema lesions in rats appear to disrupt rapid feedback inhibition of fluid intake
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DOI：
10.1016/s0006-8993(96)00277-6
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发表时间：
1996-07-08
期刊：
影响因子：
2.9
通讯作者：
Stricker, EM
中科院分区：
文献类型：
--
作者：
Curtis, KS;Verbalis, JG;Stricker, EM
采用真空抽吸法对成年雄性大鼠进行了脑后皮层损伤的研究。全身给药高渗生理盐水后，APX大鼠的饮水量明显高于正常对照大鼠。同样，服用APX的大鼠在服用高致瘤性胶体溶液时也观察到明显的低血容量。在这两种情况下，饮水量的增加都发生在饮水试验的前15分钟。APX大鼠剥夺食物后的液体日粮或10%蔗糖溶液的摄取量也明显大于对照大鼠。这些和其他结果表明，携带APX的大鼠在饮酒时对摄入的抑制更少。因此，AP对于检测由摄入液体产生的早期抑制信号可能是重要的，并且在其消融后，由于该信号提供的反馈抑制减弱，可能会出现饮酒增加。
Area postrema lesions (APX) were produced by vacuum aspiration in adult male rats. After systemic administration of hypertonic saline solutions, significantly more water was consumed by rats with APX than by intact control rats. Similarly enhanced water intake by rats with APX also was observed when marked hypovolemia was induced by s.c. administration of a hyperoncotic colloidal solution. In both conditions, the increased water intake occurred within the first 15 min of the drinking tests. Intakes of liquid diet or 10% sucrose solution after food deprivation by rats with APX also were considerably larger than those of control rats. These and other results suggest that rats with APX experience less inhibition of ingestion while drinking. Thus, the AP may be important for the detection of early, inhibitory signals generated by fluid ingestion, and after its ablation increased drinking may occur because the feedback inhibition provided by such signals is diminished.