GROWTH-FACTORS AND WOUND-HEALING
GROWTH-FACTORS AND WOUND-HEALING
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DOI：
10.3109/02844319409071186
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发表时间：
1994-06-01
影响因子：
--
通讯作者：
STEENFOS, HH
中科院分区：
文献类型：
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作者：
STEENFOS, HH
本文是根据哥德堡大学1992年的论文《生长因子与肉芽组织的形成》撰写的。在过去的十年中，人们已经认识到，生长因子对于调节肉芽组织形成和伤口愈合中涉及的细胞事件是必不可少的。最近，临床试验开始研究将生长因子和生长激素应用于人伤口的伤口愈合效果。然而，为了以智能和有效的方式在这些试验中应用生长因子，重要的是要了解它们的生理学及其在伤口愈合中的作用。本文综述了生长因子IGF-I、IGF-II、PDGF、bFGF、TGF-β、EGF、TGF-α、TNF-α、SF-HGF和生长激素在动物和人类软组织创伤愈合中的作用和影响。
This paper is based on the thesis Growth Factors and Formation of Granulation Tissue, University of Goteborg, 1992. For the last decade, it has been acknowledged that growth factors are essential for regulating the cellular events involved in the formation of granulation tissue and in wound healing. Recently, clinical trials were initiated to study the wound healing effect of applying growth factors and growth hormone to human wounds. However, in order to apply growth factors in these trials in an intelligent and effective manner, it is important to understand their physiology and their role in wound healing. This review paper is about the growth factors: IGF-I, IGF-II, PDGF, bFGF, TGF-beta, EGF, TGF-alpha, TNF-alpha, SF-HGF and Growth Hormone and their role and effect in soft tissue wound healing in animals and humans.