Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy
Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy
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负载过氧化氢酶的 TaOx 纳米壳作为生物纳米反应器，结合高 Z 元素和酶传递以增强放射治疗
DOI：
10.1002/adma.201602111
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发表时间：
2016-09-07
影响因子：
29.4
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Song, Guosheng;Chen, Yuyan;Liu, Zhuang
通过温和的一步法制备了一种在 TaOx 空心纳米壳内负载过氧化氢酶的新型生物纳米反应器。这种生物纳米反应器可以通过分解肿瘤微环境中的内源性H2O2提供氧气来有效改善肿瘤氧合，从而通过在肿瘤内沉积辐射能量和克服缺氧引起的放疗抵抗来协同增强癌症放疗的疗效。
A novel type of bio-nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia-induced radiotherapy resistance.