Work performance in iron deficiency of increasing severity.
Work performance in iron deficiency of increasing severity.
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缺铁日益严重时的工作表现。
DOI：
10.1152/jappl.1985.58.5.1477
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Dallman,PR
中科院分区：
文献类型：
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作者：
Perkkio,MV;Jansson,LT;Brooks,GA;Refino,CJ;Dallman,PR
在3 ~ 6周龄的各组大鼠中，研究了缺铁对工作能力的影响，这些大鼠的饮食中铁含量在9 ~ 50 mg/kg之间。最大耗氧量（VO2max）在血红蛋白（Hb）从14 g/dl降至8 g/dl时仅下降16%，在血红蛋白（Hb）低于7 g/dl时急剧下降。在次最大强度（耐力）的跑步机运动中，直到疲劳的持续时间在14和10 g/dl之间没有显着降低Hb。然而，在Hb为10和8 g/dl之间，耐力突然下降了73%。VO2max结果与已知的代偿机制一致，该机制有助于维持O2向组织的输送，直到贫血变得严重。相对轻微的缺铁导致耐力急剧下降，这表明缺乏对肌肉氧化能力下降的类似有效补偿。
The effect of iron deficiency on work capacity was studied in groups of rats that had received diets with iron contents ranging between 9 and 50 mg/kg diet from 3 to 6 wk of age. Maximal O2 consumption (VO2max) declined only 16% with a decrease in hemoglobin (Hb) from 14 to 8 g/dl and fell sharply only below a Hb of 7 g/dl. Duration until exhaustion in a treadmill exercise of submaximal intensity (endurance) showed no significant depression between a Hb of 14 and 10 g/dl. However, endurance declined abruptly by 73% between a Hb of 10 and 8 g/dl. The VO2max results are in accord with known compensatory mechanisms that help to maintain delivery of O2 to tissues until anemia becomes severe. The sharp fall in endurance with relatively mild iron deficiency suggests a lack of similarly effective compensations for decreased oxidative capacity of muscle.