Direct Synthesis of 1,6-Anhydro Sugars from Unprotected Glycopyranoses by Using 2-Chloro-1,3-dimethylimidazolinium Chloride
Direct Synthesis of 1,6-Anhydro Sugars from Unprotected Glycopyranoses by Using 2-Chloro-1,3-dimethylimidazolinium Chloride
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DOI：
10.1002/chin.200933196
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发表时间：
2009-05
期刊：
影响因子：
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通讯作者：
Tomonari Tanaka;Wei Huang;M. Noguchi;A. Kobayashi;S. Shoda
中科院分区：
文献类型：
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作者：
Tomonari Tanaka;Wei Huang;M. Noguchi;A. Kobayashi;S. Shoda
使用 2-氯-1,3-二甲基咪唑啉氯化物 (DMC) 作为脱水缩合剂，直接从相应的未保护的吡喃葡萄糖合成了各种 1,6-脱水糖，收率优异。反应在水介质中温和的反应条件下顺利进行。本方法将成为合成单糖、直链低聚糖和支链低聚糖的1,6-脱水衍生物的实用工具。
Various 1,6-anhydro sugars have been synthesized directly from the corresponding unprotected glycopyranoses in excellent yields by using 2-chloro-1,3-dimethylimidazolinium chloride (DMC) as a dehydrative condensing agent. The reactions took place smoothly under mild reaction conditions in aqueous media. The present method would be a practical tool for synthesis of 1,6-anhydro derivatives of monosaccharides, linear-oligosaccharides, and branched-oligosaccharides.