Prediction of Cell Wall Lytic Enzymes Using Chou's Amphiphilic Pseudo Amino Acid Composition
Prediction of Cell Wall Lytic Enzymes Using Chou's Amphiphilic Pseudo Amino Acid Composition
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DOI：
10.2174/092986609787848045
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发表时间：
2009-04-01
影响因子：
1.6
通讯作者：
Lin, Hao
中科院分区：
文献类型：
--
作者：
Ding, Hui;Luo, Liaofu;Lin, Hao
鉴别细胞壁溶酶和非溶酶是治疗细菌感染的重要任务。本文基于Chou的两亲性伪氨基酸组成，开发了基于fisher判别的细胞壁裂解酶分类器。实验结果表明，该方法灵敏度为66.7%，特异度为88.6%。该方法预测内溶素和自溶素的总准确度为92.9%。结果表明，该方法可为进一步的细菌控制研究提供有用的信息。
Discriminating cell wall lytic enzymes from non lytic enzymes is a very important task for curing bacterial infections. In this paper, based on Chou's amphiphilic pseudo amino acid composition, we develop fisher-discriminant based classifier to predict cell wall lytic enzymes. Experiments show that 66.7% sensitivity with 88.6% specificity is obtained. The method is further able to predict endolysin and autolysin with an overall accuracy of 92.9%. Results demonstrated that our method can provide highly useful information for further bacterial control research.