Associations Between Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism and Gaze Bias for Emotional Information
Associations Between Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism and Gaze Bias for Emotional Information
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DOI：
10.1037/a0022125
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发表时间：
2011-02-01
影响因子：
4.6
通讯作者：
Telch, Michael J.
中科院分区：
文献类型：
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作者：
Beevers, Christopher G.;Marti, C. Nathan;Telch, Michael J.
5-羟色胺转运体启动子区多态性（5-HTTLPR）与情绪体验相关的大脑区域对负面图像的神经反应有关。然而，这种敏感性的行为含义却没有得到广泛的研究。目前的研究使用眼动追踪方法来研究5-HTTLPR基因型的个体，包括单核苷酸多态性（SNP）rs 25531，在长时间（30秒）暴露于描绘积极和消极情绪的面部刺激时分配注意力。短5-HTTLPR等位基因携带者和携带者的长等位基因与鸟嘌呤在第六个核苷酸（S/L-G）表现出更强的注视偏差（总固定时间，固定次数，平均固定长度）积极比悲伤，威胁，或中性刺激。相比之下，那些在第六个核苷酸（L-A）上带有腺嘌呤的长5-HTTLPR等位基因的纯合子以无偏见的方式看待情感刺激。时程分析表明，最初的5-HTTLPR组间没有差异;然而，随着时间的推移，S/L-G 5-HTTLPR等位基因携带者比L-A 5-HTTLPR纯合子更有可能将目光投向快乐而不是悲伤的刺激。在信息处理的后期阶段，这种对正刺激的偏好可能反映了在5-HTTLPR S/L-G等位基因携带者中下调对负刺激的高度反应性的策略性努力。
The serotonin transporter promoter region polymorphism (5-HTTLPR) is associated with neural response to negative images in brain regions involved in the experience of emotion. However, the behavioral implications of this sensitivity have been studied far less extensively. The current study used eye-tracking methodology to examine how individuals genotyped for the 5-HTTLPR, including the single nucleotide polymorphism (SNP) rs25531, allocated attention during prolonged (30-s) exposure to face stimuli depicting positive and negative emotion. Short 5-HTTLPR allele carriers and carriers of the long allele with guanine at the sixth nucleotide (S/L-G) displayed a stronger gaze bias (total fixation time, number of fixations, mean fixation length) for positive than for sad, threat, or neutral stimuli. In contrast, those homozygous for the long 5-HTTLPR allele with adenine at the sixth nucleotide (L-A) viewed the emotion stimuli in an unbiased fashion. Time course analyses indicated no initial 5-HTTLPR group differences; however, S/L-G 5-HTTLPR allele carriers were more likely than L-A 5-HTTLPR homozygotes to direct gaze toward happy than toward sad stimuli over time. This bias toward positive stimuli during the later stages of information processing likely reflects a strategic effort to downregulate heightened reactivity to negative stimuli among 5-HTTLPR S/L-G allele carriers.