Control of bacterial exoelectrogenesis by c-AMP-GMP
Control of bacterial exoelectrogenesis by c-AMP-GMP
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DOI：
10.1073/pnas.1419264112
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发表时间：
2015-04-28
影响因子：
11.1
通讯作者：
Breaker, Ronald R.
中科院分区：
文献类型：
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作者：
Nelson, James W.;Sudarsan, Narasimhan;Breaker, Ronald R.
包括生物膜和孢子形成在内的细菌生理学的主要变化涉及环状二核苷酸c-di-GMP和c-di-AMP的信号传导。最近，发现另一种第二信使二核苷酸c-AMP-GMP控制霍乱弧菌的趋化和定殖。我们已经确定了一个superregulon的基因控制的c-AMP-GMP在许多Deltaproteobacteria，包括Geoprotea物种，使用细胞外不溶性金属氧化物作为终端电子受体。这种外生电过程已被研究，其可能的效用在能源生产和生物修复。许多参与粘附、菌毛蛋白形成和其他对外生电重要的基因由选择性结合c-AMP-GMP的变异核糖开关类的成员控制。据我们所知，这些RNA构成了第一个已知的c-AMP-GMP特异性受体，并揭示了这种分子被许多细菌用来控制专门的生理过程。
Major changes in bacterial physiology including biofilm and spore formation involve signaling by the cyclic dinucleotides c-di-GMP and c-di-AMP. Recently, another second messenger dinucleotide, c-AMP-GMP, was found to control chemotaxis and colonization by Vibrio cholerae. We have identified a superregulon of genes controlled by c-AMP-GMP in numerous Deltaproteobacteria, including Geobacter species that use extracellular insoluble metal oxides as terminal electron acceptors. This exoelectrogenic process has been studied for its possible utility in energy production and bioremediation. Many genes involved in adhesion, pilin formation, and others that are important for exoelectrogenesis are controlled by members of a variant riboswitch class that selectively bind c-AMP-GMP. These RNAs constitute, to our knowledge, the first known specific receptors for c-AMP-GMP and reveal that this molecule is used by many bacteria to control specialized physiological processes.