New T-cell epitope of Ro/SS-A 52 kDa protein in labial salivary glands from patients with Sjögren's syndrome
New T-cell epitope of Ro/SS-A 52 kDa protein in labial salivary glands from patients with Sjögren's syndrome
复制标题
干燥综合征患者唇唾液腺中 Ro/SS-A 52 kDa 蛋白的新 T 细胞表位
DOI：
10.1016/s0140-6736(05)65741-8
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
K. Nishioka
中科院分区：
文献类型：
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作者：
T. Sumida;T. Namekawa;T. Maeda;K. Nishioka
SIR-Sjögren综合征（SS）是一种自身免疫性疾病，其特征是淋巴细胞浸润到泪腺和唾液腺，导致眼睛和嘴巴干燥。肾、肺、甲状腺和肝脏也有浸润。免疫组织化学研究表明，大多数浸润淋巴细胞周围的唇唾液腺和泪腺和肾脏是CD4阳性αβ T细胞。最近对PCR1-4的研究为这些T细胞上的TRC Vβ和Vα基因提供了证据。CDR3区域的序列分析显示了一些保守的氨基酸基序，支持浸润性T细胞在自身抗原上识别相对较少的表位的观点。在炎性SS病变中，自身反应性T细胞识别的自身抗原是什么？一些观察结果表明，有三种候选的自身抗原：细胞蛋白、eb病毒（EBV）和外源性或内源性逆转录病毒。最近，Namekawa等人5报道了SS患者唇唾液腺（16个T细胞系中的4个）中Ro/SS- a 52 kDa （AA190-245）反应性T细胞的高频率，这表明Ro/SS- a 52 kDa可能是两个腺体中自身反应性T细胞的自身抗原。Ro/SS-A 52 kDa是一种主要分布在细胞质中的核糖核蛋白颗粒；然而，它也在细胞表面表达。因此，Ro/SS-A蛋白可能是被自身反应性T细胞识别的自身抗原
SIR—Sjögren’s syndrome (SS) is an autoimmune disease characterised by lymphocytic infiltration into the lacrimal and salivary glands leading to dry eyes and mouth. Infiltration is also found in the kidneys, lungs, thyroid, and liver. Immunohistochemical studies have shown that most infiltrating lymphocytes around the labial salivary and lacrimal glands, and kidney are CD4 positive αβ T cells. Recent studies with PCR1–4 provide evidence about the TRC Vβ and Vα genes on these T cells. Sequence analysis of the CDR3 region indicates some conserved aminoacid motifs, supporting the notion that infiltrating T cells recognise relatively few epitopes on autoantigens. What are the autoantigens recognised by auto-reactive T cells in inflamed SS lesions? Several observations suggest that there are three candidates for autoantigens: cell proteins, Epstein-Barr virus (EBV), and exogenous or endogenous retroviruses. Recently, Namekawa et al5 reported a high frequency of Ro/SS-A 52 kDa (AA190-245) reactive T cells in labial salivary glands from patients with SS (four of 16 T-cell lines), suggesting that Ro/SS-A 52 kDa might act as an autoantigen for autoreactive T cells in both glands. Ro/SS-A 52 kDa is a ribonucleoprotein particle distributed mainly in the cytoplasm of cells; however, it is also expressed on the cell surface. Thus, Ro/SS-A protein could be an autoantigen recognised by autoreactive T cells