Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation
Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation
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DOI：
10.1161/01.cir.95.1.213
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发表时间：
1997-01-07
期刊：
影响因子：
37.8
通讯作者：
Gutterman, DD
中科院分区：
文献类型：
--
作者：
Abe, T;Morgan, DA;Gutterman, DD
背景短暂心肌缺血后，心肌迅速产生神经生长因子（NGF）。它有助于维持几个组织的神经完整性。我们研究了外源性和内源性NGF对心肌交感神经缺血功能障碍的影响。方法和结果对麻醉犬进行双侧星状刺激，测量左冠状动脉前降支（LAD）闭塞7分钟或15分钟前后冠状动脉血管阻力（%Delta CVR）的变化。NGF (10 ng；公斤(1)。min-L, n=5)或vehicle （n=6）在犬LAD闭塞15分钟期间注入。在单独的实验中，抗NGF抗体(抗NGF， 2 ng。k(1)。min(-1), n=5)或vehicle （n=6）在7分钟LAD闭塞期间注入。释放15分钟LAD闭塞后，载药组冠状动脉收缩对星状刺激的衰减(CVR增加30+/-3%至15+/-1%，P
Background Nerve growth factor (NGF) is produced rapidly in myocardium after brief myocardial ischemia. It contributes to the maintenance of neural integrity in several tissues. We examined the effect of exogenous and endogenous NGF on ischemia-induced dysfunction of cardiac sympathetic nerves.Methods and Results In anesthetized dogs, bilateral stellate stimulation was performed, measuring changes in coronary vascular resistance (%Delta CVR) before and after release of either a 7- or 15-minute occlusion of the left anterior descending coronary artery (LAD). NGF (10 ng . kg(-1). min-L, n=5) or vehicle (n=6) was infused into the LAD in dogs during a 15-minute LAD occlusion. In separate experiments, antibody to NGF (anti-NGF, 2 ng . k(-1). min(-1), n=5) or vehicle (n=6) was infused into dogs during a 7-minute LAD occlusion. After release of a 15-minute LAD occlusion, attenuation of the coronary constriction to stellate stimulation was seen in the vehicle group (30+/-3% to 15+/-1% increase in CVR, P