The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology.
The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology.
复制标题
DOI：
10.1155/2015/281756
复制
发表时间：
2015
影响因子：
2.8
通讯作者：
Dulak J
中科院分区：
文献类型：
--
作者：
Krist B;Florczyk U;Pietraszek-Gremplewicz K;Józkowicz A;Dulak J
MicroRNA-378a （miR-378a，以前称为miR-378）是一种能够在转录后水平调节基因表达的小非编码RNA分子。它的两条成熟链，miR-378a-3p和miR-378a-5p，起源于编码PGC-1β的过氧化物酶体增殖物激活受体γ，辅助激活因子1β (ppargc1b)基因的第一个内含子。嵌入这个氧化能代谢转录调控因子的序列意味着miR-378a参与代谢途径、线粒体能量稳态和相关的生物过程，如肌肉发育、分化和再生。另一方面，miR-378a调节促血管生成因子如血管内皮生长因子、血管生成素-1或白细胞介素-8的表达，影响炎症反应，并影响肿瘤抑制因子如素复和Fus-1，被认为是肿瘤血管生成网络的一部分。在后者中，miR-378a可以通过增强细胞存活、减少细胞凋亡、促进细胞迁移和侵袭来激发更广泛的作用。本文综述了miR-378a与氧化/脂质代谢、肌肉生物学和血管形成之间的联系。
MicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature strands, miR-378a-3p and miR-378a-5p, originate from the first intron of the peroxisome proliferator-activated receptor gamma, coactivator 1 beta (ppargc1b) gene encoding PGC-1β. Embedding in the sequence of this transcriptional regulator of oxidative energy metabolism implies involvement of miR-378a in metabolic pathways, mitochondrial energy homeostasis, and related biological processes such as muscle development, differentiation, and regeneration. On the other hand, modulating the expression of proangiogenic factors such as vascular endothelial growth factor, angiopoietin-1, or interleukin-8, influencing inflammatory reaction, and affecting tumor suppressors, such as SuFu and Fus-1, miR-378a is considered as a part of an angiogenic network in tumors. In the latter, miR-378a can evoke broader actions by enhancing cell survival, reducing apoptosis, and promoting cell migration and invasion. This review describes the current knowledge on miR-378a linking oxidative/lipid metabolism, muscle biology, and blood vessel formation.