Physical activity, biliary lipids, and gallstones in obese subjects
Physical activity, biliary lipids, and gallstones in obese subjects
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DOI：
10.1016/s0002-9270(01)02447-9
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发表时间：
2001-06-01
影响因子：
9.8
通讯作者：
Lopez-S, A
中科院分区：
文献类型：
--
作者：
Chuang, CZ;Martin, LF;Lopez-S, A
目的：胆石病是美国的主要发病原因。在最近的研究中，减少体力活动已被证明是胆结石形成的危险因素;然而，解释体力活动如何防止胆结石形成的机制尚未得到很好的阐明。我们调查了体力活动，胆脂，胆结石diseases.METHODS之间的关系：三种类型的习惯性体力活动（工作，运动，休闲时间），胆脂，血脂进行了估计或测量在53名肥胖受试者接受胃旁路手术。这些体力活动被定义为在工作中的活动，在休闲时间的体育活动，在休闲时间的活动，不包括sports，respectively.RESULTS：我们发现，体育活动，而不是工作和休闲时间的活动与胆石病呈负相关。较低水平的胆汁盐和胆汁盐百分比（以总胆汁脂质的百分比表示）以及较高水平的胆固醇百分比也与胆石病相关。较低水平的体育活动似乎与较高水平的胆汁胆固醇，胆汁胆固醇百分比，血清triglycerides.CONCLUSION：我们的研究结果表明，低水平的体力活动与胆石形成。我们的研究还表明，体力活动对胆结石形成的保护作用的可能机制是降低胆汁胆固醇水平，从而防止胆固醇在胆汁中沉淀。此外，我们的数据表明，在预防胆结石疾病方面，体育活动是一种比工作和休闲活动更有效的体力活动形式。(C)2001年，我Cell.胃肠病学
OBJECTIVE: Gallstone disease is a major source of morbidity in the US. Reduced physical activity has been shown to be a risk factor for gallstone formation in recent studies; however, the mechanisms to explain how physical activity may protect against,gallstone formation have not been well elucidated. We investigated the relationships between physical activity, biliary lipids, and gallstone disease.METHODS: Three types of habitual physical activity (work, sport, and leisure time), biliary lipids, and serum lipids were estimated or measured in 53 obese subjects undergoing gastric bypass surgery. These physical activities were defined as activity at work, sport activity during leisure time, and activity during leisure time excluding sports, respectively.RESULTS: We found that sport activity but not work and leisure time activities was inversely associated with gallstone disease. Lower levels of biliary bile salts and percent biliary bile salts (expressed in percentage of total biliary lipids) and higher levels of percent cholesterol were also found to be associated with gallstone disease. A lower level of sport activity appeared to be associated with higher levels of biliary cholesterol, percent biliary cholesterol, and serum triglycerides.CONCLUSION: Our findings demonstrate that low levels of physical activity are associated with gallstone formation. Our study also suggests that a possible mechanism for the protective effect of physical activity on gallstone formation is the lowering of biliary cholesterol levels, thus preventing cholesterol from precipitating in the bile. In addition, our data suggest that sport activity is a more effective form of physical activity than working and leisure activities in the prevention of gallstone disease. (C) 2001 by Am. Cell. of Gastroenterology.