Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation
Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation
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DOI：
10.1126/science.1068438
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发表时间：
2002-03-15
期刊：
影响因子：
56.9
通讯作者：
Kerr, WG
中科院分区：
文献类型：
--
作者：
Wang, JW;Howson, JM;Kerr, WG
异基因骨髓移植后，主要组织相容性复合物（MHC）I类的自然杀伤细胞（NK）受体影响植入和移植物抗肿瘤效应。我们发现，SH 2-含有肌醇磷酸酶（SHIP）的影响NK受体的剧目。在成年SHIP-/-小鼠中，NK区室由表达两种能够结合自身或同种异体MHC配体的抑制性受体的细胞主导。这种混杂的库具有显著的功能后果，因为SHIP-/-小鼠不能排斥完全错配的同种异体骨髓移植物，并且在这种移植后显示出增强的存活率。因此，SHIP在限制同种异体骨髓移植成功的两个过程中起着重要作用：移植物排斥和移植物抗宿主病。
Natural killer cell (NK) receptors for major histocompatibility complex (MHC) class I influence engraftment and graft-versus-tumor effects after allogeneic bone marrow transplantation. We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of NK receptors. In adult SHIP-/- mice, the NK compartment is dominated by cells that express two inhibitory receptors capable of binding either self or allogeneic MHC ligands. This promiscuous repertoire has significant functional consequences, because SHIP-/- mice fail to reject fully mismatched allogeneic marrow grafts and show enhanced survival after such transplants. Thus, SHIP plays an important role in two processes that limit the success of allogeneic marrow transplantation: graft rejection and graft-versus-host disease.