Pexophagy and peroxisomal protein turnover in plants.
Pexophagy and peroxisomal protein turnover in plants.
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DOI：
10.1016/j.bbamcr.2015.09.005
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Bartel B
中科院分区：
文献类型：
--
作者：
Young PG;Bartel B
过氧化物酶体是动态的、重要的细胞器，它将各种氧化反应及其有毒副产物与细胞的其余部分隔离。过氧化物酶体代谢的氧化性质使细胞器容易受到自身造成的损伤，因此需要一种机制来处理受损的过氧化物酶体。此外，植物过氧化物酶体的代谢需求在发育过程中发生变化，过时的过氧化物酶体蛋白被降解。虽然过氧化物酶体的选择性自噬是一种明显的降解机制，但直到最近才在植物中描述过氧化物酶体的自噬。最近对参考植物拟南芥的几项研究表明，在过氧化物酶体蛋白的质量控制和过氧化物酶体含量的功能转变过程中，食酶作用与过氧化物酶体蛋白的周转有关。在这篇综述中，我们描述了我们目前对植物中食腐的发生、作用和机制的理解。
Peroxisomes are dynamic, vital organelles that sequester a variety of oxidative reactions and their toxic byproducts from the remainder of the cell. The oxidative nature of peroxisomal metabolism predisposes the organelle to self-inflicted damage, highlighting the need for a mechanism to dispose of damaged peroxisomes. In addition, the metabolic requirements of plant peroxisomes change during development, and obsolete peroxisomal proteins are degraded. Although pexophagy, the selective autophagy of peroxisomes, is an obvious mechanism for executing such degradation, pexophagy has only recently been described in plants. Several recent studies in the reference plant Arabidopsis thaliana implicate pexophagy in the turnover of peroxisomal proteins, both for quality control and during functional transitions of peroxisomal content. In this review, we describe our current understanding of the occurrence, roles, and mechanisms of pexophagy in plants.