Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees
Familial concordance of fluvoxamine response as a tool for differentiating mood disorder pedigrees
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DOI：
10.1016/s0022-3956(98)00004-1
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发表时间：
1998-09-01
影响因子：
4.8
通讯作者：
Smeraldi, E
中科院分区：
文献类型：
--
作者：
Franchini, L;Serretti, A;Smeraldi, E
在临床实践中，同一家族成员的抗抑郁反应一致性是一种常见的观察结果。然而，很少有发表的数据支持这一观点，此外，家庭与受影响的成员响应相同的抗抑郁药已经很差studied.We分析了45对情绪障碍氟伏沙明双应答先证者和一个一级亲属与已知的结果氟伏沙明治疗。在45对中，30对（67%）对氟伏沙明反应良好一致。在一致对的家族家系中，我们发现继发病例中双相型的分布显著高于非一致对的家族（14.9% vs 3.9%P = 0.039），这表明抗抑郁治疗的一致性可以选择具有较高遗传负荷的家族。(C)1998爱思唯尔科技有限公司版权所有。
Concordance to antidepressant response in members of the same family is a common observation in clinical practice. However, few published data support this view; moreover families with affected members responder to the same antidepressant have been poorly studied.We have analyzed 45 pairs consisting of one mood disorder fluvoxamine double-responder proband and one first-degree relative with known outcome to fluvoxamine treatment. Among 45 pairs 30 (67%) were concordant for good response to fluvoxamine. In family pedigrees of concordant pairs we found a significantly higher distribution of bipolar forms in secondary cases than in families of non concordant pairs (14.9% vs 3.9% P = 0.039) suggesting that concordance to antidepressant therapy could select families with higher genetic loading. (C) 1998 Elsevier Science Ltd. All rights reserved.