DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality.
DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality.
复制标题
DNA 甲基化和 2 型糖尿病：使用孟德尔随机化评估因果关系。
DOI：
10.1007/s40142-019-00176-5
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发表时间：
2019
影响因子：
2.1
通讯作者：
Juvinao-Quintero DL
中科院分区：
文献类型：
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作者：
Juvinao-Quintero DL
综述目的本综述总结了表观遗传学领域的最新进展，以了解 2 型糖尿病 (T2D) 的病因学。最新发现多个位点的 DNA 甲基化已被证明与 T2D 密切相关，包括 TXNIP、ABCG1、CPT1A 和 SREBF1。然而，由于许多流行病学研究的横截面性质以及对来自血液而不是疾病相关组织的样本的主要分析，推断因果关系很困难。因此，我们概述了使用孟德尔随机化 (MR) 作为一种能够评估 T2D 表观遗传学研究中因果关系的方法。总结流行病学研究在识别 T2D 表观遗传学标记方面取得了丰硕成果。包括利用 MR 在内的证据三角测量对于区分疾病的因果生物标志物和非因果生物标志物至关重要。更全面地了解 T2D 中表观遗传标记的因果关系将有助于优先考虑 CpG 位点作为检测疾病的早期生物标记，或在药物开发中针对表观遗传机制来治疗患者。
Purpose of ReviewThis review summarises recent advances in the field of epigenetics in order to understand the aetiology of type 2 diabetes (T2D).Recent FindingsDNA methylation at a number of loci has been shown to be robustly associated with T2D, includingTXNIP,ABCG1,CPT1A, andSREBF1. However, due to the cross-sectional nature of many epidemiological studies and predominant analysis in samples derived from blood rather than disease relevant tissues, inferring causality is difficult. We therefore outline the use of Mendelian randomisation (MR) as one method able to assess causality in epigenetic studies of T2D.SummaryEpidemiological studies have been fruitful in identifying epigenetic markers of T2D. Triangulation of evidence including utilisation of MR is essential to delineate causal from non-causal biomarkers of disease. Understanding the causality of epigenetic markers in T2D more fully will aid prioritisation of CpG sites as early biomarkers to detect disease or in drug development to target epigenetic mechanisms in order to treat patients.