Iron-Catalyzed Suzuki-Miyaura Coupling of Alkyl Halides
Iron-Catalyzed Suzuki-Miyaura Coupling of Alkyl Halides
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DOI：
10.1021/ja103973a
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发表时间：
2010-08-11
影响因子：
15
通讯作者：
Nakamura, Masaharu
中科院分区：
文献类型：
--
作者：
Hatakeyama, Takuji;Hashimoto, Toru;Nakamura, Masaharu
在新型氯化铁-二膦配合物和溴化镁存在下，芳基硼酸锂与伯、仲卤代烷反应，得到相应的偶联产物，产率从好到优。高官能团相容性也在具有反应性取代基（例如烷氧基羰基、氰基和羰基）的底物的反应中得到证实。
In the presence of novel iron(II) chloride-diphosphine complexes and magnesium bromide, lithium arylborates react with primary and secondary alkyl halides to give the corresponding coupling products in good to excellent yields. High functional group compatibility is also demonstrated in the reactions of substrates possessing reactive substituents, such as alkoxycarbonyl, cyano, and carbonyl groups.