DEFINITION OF CHEMICAL DIABETES
DEFINITION OF CHEMICAL DIABETES
复制标题
DOI：
10.1016/0026-0495(73)90163-7
复制
发表时间：
1973-01-01
影响因子：
9.8
通讯作者：
FAJANS, SS
中科院分区：
文献类型：
--
作者：
FAJANS, SS
糖尿病的自然史可以根据是否存在异常碳水化合物代谢而任意分为四个阶段。显性糖尿病是最晚期的阶段，其特征是空腹血糖浓度升高和典型症状。这个阶段分为酮型和非酮型。显性糖尿病之前是潜伏性或化学性糖尿病阶段，没有糖尿病症状，但口服或静脉内葡萄糖耐量明显异常。亚临床糖尿病是一个早期阶段，当葡萄糖耐量异常时，只有压力，如怀孕或可的松的管理。糖尿病前期是最早的阶段，从怀孕开始，一直到首次出现明显的糖耐量异常。在假定的糖尿病前期个体中，已经注意到延迟和/或降低的血浆胰岛素对葡萄糖的反应。糖尿病的进展可能不会发生，可能发生得非常缓慢或非常迅速，也可能发生退化到早期异常阶段。
The natural history of diabetes mellitus can be arbitrarily divided into four stages based on the presence or absence of abnormal carbohydrate metabolism. Overt diabetes is the most advanced stage, characterized by elevated fasting blood glucose concentration and classical symptoms. This stage is divided into ketotic and nonketotic forms. Preceding overt diabetes is the latent or chemical diabetic stage, with no symptoms of diabetes but demonstrable abnormality of oral or intravenous glucose tolerance. Subclinical diabetes is an earlier stage when glucose tolerance is abnormal only with stress, such as pregnancy or the administration of cortisone. The earliest stage, prediabetes, extends from conception until the first demonstrable abnormality in glucose tolerance. In groups of presumed prediabetic individuals, delayed and/or decreased plasma insulin response to glucose has been noted. Progression of the diabetes may not occur, may occur very slowly or very rapidly, and regression to an earlier stage of abnormality may also occur.