Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma
Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma
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DOI：
10.21873/anticanres.11802
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发表时间：
2017-08-01
影响因子：
2
通讯作者：
Kuwano, Hiroyuki
中科院分区：
文献类型：
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作者：
Honjo, Hiroaki;Toh, Yasushi;Kuwano, Hiroyuki
背景/目的：转移相关基因 1 (MTA1) 被认为是食管癌的潜在预后因素。我们通过正电子发射断层扫描 (PET) 评估食管鳞状细胞癌中 MTA1、LAT1 和肿瘤代谢之间的临床关系。材料和方法：我们分析了 142 例未经术前治疗而接受根治性切除的食管鳞状细胞癌患者。通过免疫组织化学评估 MTA1 表达，并根据术前 PET-CT 的标准化摄取值进行测试。分析了 MTA1、LAT1 和 (18)FAMT PET 结果之间的关联。结果：142 个癌组织中的 82 个组织中观察到 MTA1 染色。在没有 MTA1 的情况下，五年总生存率为 69.9%，否则为 50.7% (p=0.021)，而无病生存率分别为 66.5% 和 49.0% (p=0.071)。在 13 名无 MTA1 的患者和 18 名有 MTA1 的患者中发现 18FAMT 积累异常 (p=0.079)，最大标准化摄取值分别为 1.6 +/- 1.6 和 2.7 +/- 1.6 (p=0.036)。 MTA1 表达与 LAT1 (p=0.013) 和 CD34 (p=0.034) 表达呈正相关，但与 Ki-67 (p=0.078) 不相关。结论：MTA1有望成为食管癌的诊断和预后标志物，我们预计该基因也将被证明是一个良好的治疗靶点。
Background/Aim: Metastasis-associated gene 1 (MTA1) is considered a potential prognostic factor in esophageal cancer. We investigated the clinical relationship between MTA1, LAT1, and tumor metabolism, as evaluated by positron emission tomography (PET) in esophageal squamous cell carcinoma. Materials and Methods: We analyzed 142 esophageal squamous cell carcinoma patients who underwent curative resection without preoperative treatment. MTA1 expression was assessed by immuno-zahistochemistry, and tested against standardized uptake values from preoperative PET-CT. The association among MTA1, LAT1, and (18)FAMT PET results were analyzed. Results: MTA1 staining was observed in 82 of 142 cancer tissues. Five-year overall survival was 69.9 % in the absence of MTA1, but 50.7% otherwise (p=0.021), while disease-free survival was 66.5% and 49.0% (p=0.071), respectively. Abnormal 18FAMT accumulation was noted in 13 patients without MTA1 and in 18 patients with MTA1 (p=0.079), with maximum standardized uptake value 1.6 +/- 1.6 and 2.7 +/- 1.6, respectively (p=0.036). MTA1 expression was positively correlated with LAT1 (p=0.013) and CD34 (p=0.034) expression, but not with Ki-67 (p=0.078). Conclusion: MTA1 shows promise as a diagnostic and prognostic marker in esophageal cancer, and we anticipate that the gene will also prove to be a good therapeutic target.