Regulation of meiotic chromatin loop size by chromosomal position
Regulation of meiotic chromatin loop size by chromosomal position
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DOI：
10.1073/pnas.93.7.2795
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发表时间：
1996-04-02
影响因子：
11.1
通讯作者：
Moens, PB
中科院分区：
文献类型：
--
作者：
Heng, HHQ;Chamberlain, JW;Moens, PB
在减数分裂前期，染色质环围绕蛋白质核心，这些环的大小在物种之间变化。在转基因小鼠中不同位点处的序列相关插入物的形态学的比较表明，环大小也随染色体地理学而变化。类似地，染色质环长度对于末端和末端定位的仓鼠端粒序列显著不同。位于染色体末端，与减数分裂的蛋白质核心紧密相关，形成比相同的间质序列更短的环。因此，我们提出证据表明，对于间质与末端染色体区域存在不同的染色质包装机制，其与在DNA序列水平上操作的那些分开作用，染色体位置在染色质包装中起着主导作用。
At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species, Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography, Similarly, chromatin loop lengths differ dramatically for interstitially and terminally located hamster telomeric sequences, Sequences, telomeric or otherwise, located at chromosome termini, closely associate with the meiotic proteinaceous core, forming shorter loops than identical interstitial sequences, Thus, we present evidence that different chromatin packaging mechanisms exist for interstitial versus terminal chromosomal regions, which act separately from those operating at the level of the DNA sequence, Chromosomal position plays the dominant role in chromatin packaging.