Association of B-Type Natriuretic Peptide Levels With Estimated Glomerular Filtration Rate and Congestive Heart Failure
Association of B-Type Natriuretic Peptide Levels With Estimated Glomerular Filtration Rate and Congestive Heart Failure
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DOI：
10.3121/cmr.2009.867
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发表时间：
2010-03-01
影响因子：
1.4
通讯作者：
Dart, Richard A.
中科院分区：
文献类型：
--
作者：
Wiley, Carmen L.;Switzer, Sean P.;Dart, Richard A.
背景：B 型利钠肽 (BNP) 水平升高的原因是多因素的。一些研究表明，肾功能障碍会影响 BNP 水平，并且 BNP 水平在慢性肾脏疾病中的诊断价值受到质疑。先前的研究涉及的患者群体较小，结果各异。本研究评估了 BNP 水平与估计肾小球滤过率 (eGFR) 以及是否存在充血性心力衰竭 (CHF) 的关联。方法：一项回顾性横断面研究，其中电子筛选医疗记录，确定了 2002 年 12 月至 2006 年 3 月期间同一天进行 BNP 水平和血清肌酐测量的患者。结果：在 1739 名符合条件的患者中，537 名 CHF 呈阳性，根据我们的标准，1202 人的 CHF 呈阴性。根据纽约心脏协会 (NYHA) 分类，随着 CHF 的进展，BNP 有明显升高的趋势 (P < 0.001)。中位 BNP 水平从无 CHF 患者的 65 pg/mL 增至 NYHA IV 级 CHF 患者的 496 pg/mL（P
Background: The causes of elevated B-Type natriuretic peptide (BNP) levels are multifactorial. Renal dysfunction has been shown to affect BNP levels in some studies and the diagnostic value of BNP levels in the presence of chronic kidney disease has been questioned. Prior studies have involved small patient populations with variable outcomes noted. This study evaluated the association of BNP levels with an estimated glomerular filtration rate (eGFR) and presence or absence of congestive heart failure (CHF).Methods: A retrospective, cross-sectional study in which medical records were electronically screened, identified patients with a BNP level and serum creatinine measurement on the same day between December 2002 and March 2006.Results: Of 1739 eligible patients, 537 were positive for CHF and 1202 were negative for CHF by our criteria. There was a clear trend for BNP to be higher with the advancement of CHF, as determined by New York Heart Association (NYHA) classification (P < 0.001). Median BNP levels increased from 65 pg/mL in patients without CHF to 496 pg/mL in patients with NYHA class IV CHF (P