Potential Microfluidic Devices for COVID-19 Antibody Detection at Point-of-Care (POC): A Review
Potential Microfluidic Devices for COVID-19 Antibody Detection at Point-of-Care (POC): A Review
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DOI：
10.1109/jsen.2020.3034892
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发表时间：
2020-10
影响因子：
4.3
通讯作者：
M. Tayyab;M. Sami;H. Raji;Srinivas Mushnoori;M. Javanmard
中科院分区：
文献类型：
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作者：
M. Tayyab;M. Sami;H. Raji;Srinivas Mushnoori;M. Javanmard
Covid-19被宣布为全球大流行，使世界经济和社会停滞不前。当前测试的重点是检测SARS-COV-2的遗传物质。此类测试对于评估受试者的当前状态很有用：感染或未感染。除了此类测试外，还必须进行抗体测试，以将种群分为三组：从未暴露，感染和免疫。这样的分层对于安全重新开放社会并重新启动经济是必要的。这篇评论文章的目的是告知听众当前用于检测SARS-COV-2抗体的诊断和监视技术以及它们的缺点，并突出显示微流体传感器和设备，这些传感器和设备显示出有望被商业化的有望用于检测和定量低资源和护理（POC）设置中的SARS-COV-2抗体。
COVID-19 has been declared a global pandemic which has brought the world economy and the society to a standstill. The current emphasis of testing is on detection of genetic material of SARS-CoV-2. Such tests are useful for assessing the current state of a subject: Infected or not infected. In addition to such tests, antibody testing is necessary to stratify the population into three groups: never exposed, infected, and immune. Such a stratification is necessary for safely reopening the society and remobilizing the economy. The aim of this review article is to inform the audience of the current diagnostic and surveillance technologies that are being employed for the detection of SARS-CoV-2 antibodies along with their shortcomings, and to highlight microfluidic sensors and devices that show promise of being commercialized for detection and quantification of SARS-CoV-2 antibodies in low-resource and Point-of-Care (POC) settings.