Little and often: Ingestive behavior patterns following hippocampal lesions in rats
Little and often: Ingestive behavior patterns following hippocampal lesions in rats
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DOI：
10.1037/0735-7044.112.3.502
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发表时间：
1998-06-01
影响因子：
1.9
通讯作者：
Somerville, EM
中科院分区：
文献类型：
--
作者：
Clifton, PG;Vickers, SP;Somerville, EM
病变的背侧和腹侧海马产生的兴奋性毒素AMPA的多次输注。在损伤前后记录的进食模式显示总食物摄入量没有变化，但有一种显著的行为综合征，即损伤大鼠进食较少的食物的频率是损伤大鼠的2-3倍，并且在饮酒方面显示出类似的变化。此外，在一次摄食行为中，受损大鼠更频繁地在进食和饮水之间交替。在进餐后的饱腹感序列中没有组间差异。在一个开放的领域测试中，损伤的大鼠表现出增强的运动在周边和减少饲养。嗅觉习惯化-去适应化任务显示，损伤大鼠对嗅觉刺激的研究较少，但对改变的刺激的去适应化是正常的。数据进行了讨论的行为转换或可能的内感受性失认海马损伤后的变化。
Lesions of both dorsal and ventral hippocampus were produced by multiple infusions of the excitotoxin AMPA. Meal patterns recorded before and after lesioning showed no change in total food intake, but a striking behavioral syndrome in which the lesioned rats took smaller meals 2-3 times as frequently and showed a similar change in drinking. In addition, lesioned rats alternated more frequently between feeding and drinking during a single bout of ingestive behavior. There were no group differences in the satiety sequence that followed a meal. In an open field test, lesioned rats showed enhanced locomotion in the periphery and reduced rearing. An olfactory habituation-dishabituation task showed that the lesioned rats investigated olfactory stimuli less but dishabituation to a changed stimulus was normal. The data are discussed in terms of changes in behavioral switching or a possible interoceptive agnosia following hippocampal damage.