Serum Vitamin A Levels May Affect the Severity of Ocular Graft-versus-Host Disease.
Serum Vitamin A Levels May Affect the Severity of Ocular Graft-versus-Host Disease.
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血清维生素 A 水平可能影响眼移植物抗宿主病的严重程度
DOI：
10.3389/fmed.2017.00067
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发表时间：
2017
影响因子：
3.9
通讯作者：
Jin X
中科院分区：
文献类型：
--
作者：
Tong J;Hu R;Zhao Y;Xu Y;Zhao X;Jin X
异基因造血干细胞移植（HSCT）是一种成熟的治疗选择，用于治疗一系列遗传性和获得性血液病。然而，移植物抗宿主病（GVHD）仍然是异基因造血干细胞移植受者非复发死亡的主要原因。高达80%的慢性GVHD患者发生眼部受累。在我们的病例中，维生素A缺乏的诊断被怀疑为GVHD患者。进行血清维生素A测量以确认临床怀疑。我们的研究显示慢性肝脏GVHD患者血清维生素A水平显著降低。虽然已经有许多研究评估GVHD患者的眼部表现，但据我们所知，本研究是第一个研究维生素A与人类GVHD眼部表现之间关系的研究。我们的数据表明，维生素A缺乏影响成人眼部GVHD的严重程度。
Allogeneic hematopoietic stem cell transplantation (HSCT) is a well-established therapeutic option for a range of inherited and acquired hematological disorders. However, graft-versus-host disease (GVHD) remains the leading cause of non-relapse mortality in allogeneic HSCT recipients. Ocular involvement occurs in up to 80% of chronic GVHD patients. In our cases, the diagnosis of vitamin A deficiency was suspected for GVHD patients. Serum vitamin A measurements were conducted to confirm clinical suspicions. Our study revealed significant decrease in serum levels of vitamin A in chronic liver GVHD patients. Although there have been many studies evaluating ocular manifestations in patients with GVHD, the present study is, to our knowledge, the first to study the relationship between vitamin A and ocular manifestations of GVHD in humans. Our data suggest that vitamin A deficiency affects the severity of ocular GVHD in adults.