Efficient and stereocontrolled synthesis of polysubstituted tetrahydropyrans by an allylstannylation/Bi(III)-promoted cyclisation strategy
Efficient and stereocontrolled synthesis of polysubstituted tetrahydropyrans by an allylstannylation/Bi(III)-promoted cyclisation strategy
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DOI：
10.1016/s0040-4039(01)01836-6
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发表时间：
2001-12-03
影响因子：
1.8
通讯作者：
Markó, IE
中科院分区：
文献类型：
--
作者：
Leroy, B;Markó, IE
一种新的序列，涉及高度官能化的烯丙基锡烷和各种醛之间的缩合，然后由三氟甲磺酸铋促进的分子内樱井环化（IMSC）的所得高烯丙基醇，允许快速和立体控制的访问范围内的多取代四氢吡喃。(C)2001爱思唯尔科技有限公司版权所有。
A novel sequence, involving the condensation between a highly functionalised allylstannane and various aldehydes, followed by a bismuth triflate-promoted intramolecular Sakurai cyclisation (IMSC) of the resulting homoallylic alcohols, allows a rapid and stereocontrolled access to a range of polysubstituted tetrahydropyrans. (C) 2001 Elsevier Science Ltd. All rights reserved.