A study on dichlorvos induced hematology, clinical biochemistry and reproductive abnormalities in male albino rats. -

A study on dichlorvos induced hematology, clinical biochemistry and reproductive abnormalities in male albino rats. -
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敌敌畏诱导雄性白化大鼠血液学、临床生化和生殖异常的研究。

DOI：
10.5455/jmp.20170120013607
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发表时间：
2017
期刊：
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影响因子：
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通讯作者：
Benson Chukwunonso Agina
Benson Chukwunonso Agina
中科院分区：
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文献类型：
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作者：
O. Agina;V. U. Omoja;S. O. Ekere;S. Odo;Benson Chukwunonso Agina

文献摘要

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目的/背景：敌敌畏（Otapiapia®）是一种当地配方的未指定杀虫剂，作为家庭驱虫剂不加区分地使用。它被用作杀螨剂、杀鼠剂和肉毒杆菌剂。本研究评价了口服该敌敌畏对雄性白化大鼠血液学、血清生化及附睾尾部精子储备的影响。方法：将40只雄性白化大鼠随机分为A、B、C、D 4组，置于镀锌笼中。A、B、C组分别通过胃管口服4、2、1 mg/kg otapiapia®，每日28 D； D组以蒸馏水10 ml/kg为对照。所有血液学、血清生化和附睾尾部精子（CESR）分析均按照标准程序进行。结果：除血清ALP和肌酐值外，两组血液学、血清生化指标及附睾尾部精子储备均有显著差异（P < 0.05）。结论：本研究中使用的敌敌畏（otapiapia®）口服可导致贫血、严重白细胞增多、高蛋白血症、高球蛋白血症、低胆固醇血症、高血糖和附睾精子储备降低。
Aim/Background: Dichlorvos (Otapiapia®) is a locally formulated unspecified insecticide applied indiscriminately as a household repellant. It is used as an acaricide, rodenticide and botacide. This study evaluated the effect of oral administration of this dichlorvos on the hematology, serum biochemistry and cauda epididymal sperm reserve of male albino rats. Methods: Forty male albino rats were randomly assigned in to four groups designated A, B, C and D in galvanized cages. Groups A, B and C were dosed orally using orogastric cannula with 4, 2, and 1 mg/kg of otapiapia® respectively, daily for 28 days while group D received 10 ml/kg distilled water, and served as the control. All hematological, serum biochemistry and cauda epididymal sperm (CESR) analyses were done following standard procedures. Results: Significant (P < 0.05) differences were recorded in all the hematological and serum biochemistry parameters and cauda epididymal sperm reserve except in the serum ALP and creatinine values. Conclusion: Oral administration of dichlorvos (otapiapia®) as used in this study led to anemia, severe leukocytosis, hyperproteinemia, hyperglobulinemia, hypocholesterolemia, hyperglycemia and decreased epididymal sperm reserve.