Ultrafast laser based "green" synthesis of non-toxic nanoparticles in aqueous solutions
Ultrafast laser based "green" synthesis of non-toxic nanoparticles in aqueous solutions
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DOI：
10.1007/s00339-008-4773-y
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发表时间：
2008-12-01
影响因子：
2.7
通讯作者：
Meunier, M.
中科院分区：
文献类型：
--
作者：
Besner, S.;Kabashin, A. V.;Meunier, M.
无机纳米粒子为生物传感和成像以及治疗提供了新的有前途的特性。然而，这些应用通常由于常规纳米材料的可能毒性而变得复杂，这是由于通过使用有毒或非生物相容性物质的合成途径获得的纳米颗粒的纯化程序不充分而引起的。本文综述了飞秒激光辅助制备金属纳米材料的新方法，这些方法可以在清洁、生物友好的水环境中制备金属纳米材料（“绿色”合成），从而彻底解决了毒性问题。所提出的方法，包括激光烧蚀和破碎，使得生产具有极小尺寸（类似于2nm）的稳定金属胶体成为可能，其具有低的变异系数（15-25%）。这些纳米颗粒表现出独特的表面化学，可用于生物成像，癌症治疗和纳米颗粒增强拉曼光谱。
Inorganic nanoparticles offer novel promising properties for biological sensing and imaging, as well as in therapeutics. However, these applications are often complicated by the possible toxicity of conventional nanomaterials, arising as a result of inadequate purification procedures of nanoparticles obtained via synthetic pathways using toxic or non-biocompatible substances. We review novel femtosecond laser-assisted methods, which enable the preparation of metal nanomaterials in clean, biologically friendly aqueous environment ("green" synthesis) and thus completely solve the toxicity problem. The proposed methods, including laser ablation and fragmentation, make possible the production of stable metal colloids of extremely small size (similar to 2 nm) with a low coefficient of variation (15-25%). Those nanoparticles exhibit unique surface chemistry and can be used for bio-imaging, cancer treatment and nanoparticle-enhanced Raman spectroscopy.