DESPITE A MASSIVE INCREASE IN CORTISOL SECRETION IN WOMEN DURING PARTURITION, THERE IS AN EQUALLY MASSIVE INCREASE IN PROSTAGLANDIN SYNTHESIS - A PARADOX
DESPITE A MASSIVE INCREASE IN CORTISOL SECRETION IN WOMEN DURING PARTURITION, THERE IS AN EQUALLY MASSIVE INCREASE IN PROSTAGLANDIN SYNTHESIS - A PARADOX
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DOI：
10.1172/jci111899
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发表时间：
1985-01-01
影响因子：
15.9
通讯作者：
MITCHELL, MD
中科院分区：
文献类型：
--
作者：
CASEY, ML;MACDONALD, PC;MITCHELL, MD
显而易见的悖论是，有一个同时增加生产的前列腺素和皮质醇的妇女在分娩期间提出了研究。这就产生了一个悖论，因为在大多数组织中，皮质醇的作用是抑制前列腺素的形成。利用先前表征的模型系统体外研究羊膜、蜕膜和子宫肌层中花生四烯酸的代谢，单层培养中羊膜和子宫内膜间质细胞的前列腺素分泌并未显示出糖皮质激素治疗的减少。地塞米松（10-7 M）对培养肌平滑肌细胞的前列腺素分泌有90%的抑制作用。重要的是，子宫肌层以及培养的子宫肌平滑肌细胞产生的主要前列腺素是前列环素，这种前列腺素的作用是使子宫静止。羊膜和蜕膜对糖皮质激素的免疫作用可能加速前列腺素E2和f2 - α的产生。，导致子宫肌收缩；同时，分娩妇女体内大量产生的糖皮质激素可能导致子宫肌层产生的前列环素减少，从而减少子宫静止。在这种协调的方式下，子宫收缩在胎儿分娩时达到高潮，面对增加的皮质醇产生可能不间断地进行。
The apparent paradox that is posed by the fact that there is a simultaneous increase in the production of prostaglandin and cortisol in women during labor was studied. A paradox obtains, since in most tissues, cortisol acts to inhibit prostaglandin formation. Using previously characterized model systems for the in vitro study of arachidonic acid metabolism in amnion, decidua and myometrium, prostaglandin production by amnion and endometrial stromal cells in monolayer culture was not shown to decrease by glucocorticosteroid treatment. Prostaglandin production by myometrial smooth muscle cells in culture was inhibited by > 90% in response to dexamethasone (10-7 M) treatment. Importantly, the major prostaglandin produced by myometrium, as well as myometrial smooth muscle cells in culture, is prostacyclin, a prostaglandin that acts to cause uterine quiescence. The immunity of amnion and decidua to the action of glucocorticosteroids may allow for the accelerated production of prostaglandins E2 and F2.alpha., which act to cause myometrial contractions; simultaneously, glucocorticosteroid produced in large quantitites in women in labor may lead to decreased production of prostacyclin by myometrium, thereby reducing uterine quiescence. In this coordinated manner, the uterine contractions that culminate in delivery of the fetus may proceed uninterrupted in the face of increased cortisol production.