Multisite fMRI reproducibility of a motor task using identical MR systems
Multisite fMRI reproducibility of a motor task using identical MR systems
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DOI：
10.1002/jmri.21118
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发表时间：
2007-10-01
影响因子：
4.4
通讯作者：
Amaro, Edson, Jr.
中科院分区：
文献类型：
--
作者：
Costafreda, Sergi G.;Brammer, Michael J.;Amaro, Edson, Jr.
目的：为了估计扫描仪之间的功能性MRI（fMRI）的再现性在multisite study.Materials和方法：共5个相同的1.5T MR系统被用来重复扫描5名受试者，同时执行手指敲击任务。双向随机效应方差分析（ANOVA）用于估计两个结果变量的扫描仪间和受试者间变异性：任务相关的平均血氧水平依赖（BOLD）信号变化和运动感兴趣区域（ROI）内的激活量。fMRI数据的扫描仪间变异性占BOLD信号变化总变异的一小部分（8.34%，P = 0.114）和激活体积（5.46%，P = 0.203）。受试者间变异占总变异的一半以上（分别为57.17%和54.46%，P < 0.01）。
Purpose: To estimate between-scanner functional MRI (fMRI) reproducibility in a multisite study.Materials and Methods: A total of five identical 1.5T MR systems were used to repeatedly scan five subjects while performing a finger tapping task. A two-way (scanners, subjects) random effects analysis of variance (ANOVA) was used to estimate between-scanner and between-subject variability on two outcome variables: task-related mean blood oxygenation level dependent (BOLD) signal change and volume of activation within a motor region-of-interest (ROI).Results: Between-scanner variability of fMRI data accounted for a small proportion of the total variation in the BOLD signal change (8.34%, P = 0.114) and volume of activation (5.46%, P = 0.203). Between-subject variation accounted for more than half of the total variation for both measurements (57.17% and 54.46%, respectively, P < 0.01).Conclusion: These results support the feasibility of multisite studies using identical scanner systems.