MICROSCOPIC PULMONARY TUMOR EMBOLI ASSOCIATED WITH DYSPNEA
MICROSCOPIC PULMONARY TUMOR EMBOLI ASSOCIATED WITH DYSPNEA
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DOI：
10.1002/1097-0142(197510)36:4
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发表时间：
1975-01-01
期刊：
影响因子：
6.2
通讯作者：
NOCE, PS
中科院分区：
文献类型：
--
作者：
KANE, RD;HAWKINS, HK;NOCE, PS
描述了一种综合征，在尸检中发现严重的、临床原因不明的呼吸困难是由多个显微肿瘤栓子引起的。16例肺动脉多发微小肿瘤栓子中有8例出现这种情况，但未见明显的淋巴管或肺实质受累。癌栓的来源包括前列腺癌、乳腺癌、胃癌、胰腺癌和肝癌。在8例出现原因不明的呼吸困难的病例中，最初的体格检查、X线片和心电检查均不能确诊。在这8例中只有5例有肺心病的临床或形态学证据。肿瘤栓子不侵犯肺血管壁，但常伴有血栓。随着癌症治疗的进展，对这种临床病理实体的认识变得重要。
A syndrome is described in which severe, clinically unexplained dyspnea is found at autopsy to be caused by multiple microscopic tumor emboli. Such a situation was found in 8 of 16 cases of multiple microscopic tumor emboli in the pulmonary arteries without significant lymphatic or parenchymal involvement of the lungs. The origins of tumor emboli included carcinomas of the prostate, breast, stomach, pancreas, and liver. In the 8 cases that presented with unexplained dyspnea, initial physical, roentgenographic, and electro‐cardiographic examinations were not diagnostic. Clinical or morphological evidence of cor pulmonale was present in only 5 of these 8 cases. The tumor emboli did not invade the walls of pulmonary vessels but were frequently associated with thrombi. Recognition of this clinicopathologic entity becomes important as progress is made in cancer therapy.