Systematic identification of correlates of HIV infection: an X-wide association study
Systematic identification of correlates of HIV infection: an X-wide association study
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DOI：
10.1097/qad.0000000000001767
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发表时间：
2018-04-24
期刊：
影响因子：
3.8
通讯作者：
Bendavid, Eran
中科院分区：
文献类型：
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作者：
Patel, Chirag J.;Bhattacharya, Jay;Bendavid, Eran
目标：更好地识别高危人群有助于艾滋病毒1护理方案。我们系统地确定了HIV-1的危险因素，在两个全国代表性的妇女队列中的人口和健康Surveys.Methods：我们确定和复制的1415社会，经济，环境和行为因素与HIV-1状态的关联。我们使用了2007年和2013-2014年分别在5715名和15433名赞比亚妇女中进行的调查（688个共同因素）。我们使用错误发现率标准来确定整个人群的单变量和多变量模型中与HIV-1密切相关的因素，以及按财富，居住地，年龄和既往HIV-1检测分层的亚组。在单变量分析中，我们在两项调查中确定了102和182个与HIV-1相关的变量，（共79个因素）。在全样本分析和亚组中与HIV-1状态相关的因素包括曾经结婚（调整OR 2007，2.8，P < 10（-16）; 2013-2014 2.8，P < 10（-29）），丧偶（aOR 3.7，P < 10（-12）; 4.2，P < 10（-30）），12个月内生殖器溃疡（aOR 2.4，P < 10（-5）;和2.2，P < 10（-6）），并且有女性户主（aOR 1.7，P < 10（-7）;和2.1，P < 10（-26）），而拥有自行车（aOR 0.6，P < 10（-6）;和0.6，P < 10（-8））和目前母乳喂养（aOR 0.5，P < 10（-9）;和0.4，P < 10（-26））与风险降低相关。HIV-1阳性率曲线下面积为0.76- 0.82。结论：本研究发现了与HIV-1感染有关的未被充分认识的因素，包括丧偶、母乳喂养和户主性别。这些特征可用于改进HIV-1识别程序。版权所有（C）2018作者。由Wolters Kluwer Health，Inc.出版。
Objective: Better identification of at-risk groups could benefit HIV-1 care programmes. We systematically identified HIV-1 risk factors in two nationally representative cohorts of women in the Demographic and Health Surveys.Methods: We identified and replicated the association of 1415 social, economic, environmental, and behavioral factors with HIV-1 status. We used the 2007 and 2013-2014 surveys conducted among 5715 and 15433 Zambian women, respectively (688 shared factors). We used false discovery rate criteria to identify factors that are strongly associated with HIV-1 in univariate and multivariate models of the entire population, as well as in subgroups stratified by wealth, residence, age, and past HIV-1 testing.Results: In the univariate analysis, we identified 102 and 182 variables that are associated with HIV-1 in the two surveys, respectively (79 factors were associated in both). Factors that were associated with HIV-1 status in full-sample analyses and in subgroups include being formerly married (adjusted OR 2007, 2.8, P < 10(-16); 2013-2014 2.8, P < 10(-29)), widowhood (aOR 3.7, P < 10(-12); and 4.2, P < 10(-30)), genital ulcers within 12 months (aOR 2.4, P < 10(-5); and 2.2, P < 10(-6)), and having a woman head of the household (aOR 1.7, P < 10(-7); and 2.1, P < 10(-26)), while owning a bicycle (aOR 0.6, P < 10(-6); and 0.6, P < 10(-8)) and currently breastfeeding (aOR 0.5, P < 10(-9); and 0.4, P < 10(-26)) were associated with decreased risk. Area under the curve for HIV-1 positivity was 0.76-0.82.Conclusion: Our X-wide association study identifies under-recognized factors related to HIV-1 infection, including widowhood, breastfeeding, and gender of head of the household. These features could be used to improve HIV-1 identification programs. Copyright (C) 2018 The Author(s). Published by Wolters Kluwer Health, Inc.