Chemokines and Chemokine Receptors Critical to Host Resistance following Genital Herpes Simplex Virus Type 2 (HSV-2) Infection.
Chemokines and Chemokine Receptors Critical to Host Resistance following Genital Herpes Simplex Virus Type 2 (HSV-2) Infection.
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DOI：
10.2174/1874226200801010033
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Carr, D J J
中科院分区：
文献类型：
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作者：
Thapa, M;Carr, D J J
HSV-2是一种非常成功的人类病原体，具有通过产生病毒编码的蛋白质来逃避免疫检测或对抗先天性和适应性免疫应答的显著能力。响应于感染，驻留细胞分泌可溶性因子，包括趋化因子，其动员和引导白细胞（包括T和NK细胞）、嗜中性粒细胞和单核细胞至感染部位。虽然系统内存在内置冗余，但趋化因子通过特定的膜结合受体发出信号，这些受体充当天线，详细描述了一种化学途径，这将提供一种定位和消除病毒侵害的方法。在中枢神经系统（CNS），时间和空间表达的趋化因子相对于白细胞动员响应HSV-2感染尚未阐明。本文将审查一些趋化因子/趋化因子受体候选人，出现关键的主机在病毒耐药性和清除从中枢神经系统和外周组织使用生殖器HSV-2感染的小鼠模型。
HSV-2 is a highly successful human pathogen with a remarkable ability to elude immune detection or counter the innate and adaptive immune response through the production of viral-encoded proteins. In response to infection, resident cells secrete soluble factors including chemokines that mobilize and guide leukocytes including T and NK cells, neutrophils, and monocytes to sites of infection. While there is built-in redundancy within the system, chemokines signal through specific membrane-bound receptors that act as antennae detailing a chemical pathway that will provide a means to locate and eliminate the viral insult. Within the central nervous system (CNS), the temporal and spatial expression of chemokines relative to leukocyte mobilization in response to HSV-2 infection has not been elucidated. This paper will review some of the chemokine/chemokine receptor candidates that appear critical to the host in viral resistance and clearance from the CNS and peripheral tissue using murine models of genital HSV-2 infection.