Strategies for nanoplasmonic core-satellite biomolecular sensors: Theory-based Design
Strategies for nanoplasmonic core-satellite biomolecular sensors: Theory-based Design
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DOI：
10.1063/1.3254756
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发表时间：
2009-11-09
影响因子：
4
通讯作者：
Lee, Luke P.
中科院分区：
文献类型：
--
作者：
Ross, Benjamin M.;Waldeisen, John R.;Lee, Luke P.
本文利用广义多粒子Mie形式对核-卫星金纳米粒子组合进行了系统的理论研究。我们考虑了卫星数量、卫星半径、核心半径和卫星距离的重要性，并提出了优化由于卫星附着或释放而引起的光谱偏移的方法。这为提高分子检测的灵敏度和信噪比提供了明确的策略，使简单的比色分析成为可能。我们通过引入绩效指标来量化这些策略的绩效。此外，我们还提供了对控制核心-卫星纳米组件光学响应的纳米等离子体相互作用的更好理解。(C) 2009年美国物理研究所。(doi: 10.1063/1.3254756)
We present a systematic theoretical study of core-satellite gold nanoparticle assemblies using the Generalized Multiparticle Mie formalism. We consider the importance of satellite number, satellite radius, the core radius, and the satellite distance, and we present approaches to optimize spectral shift due to satellite attachment or release. This provides clear strategies for improving the sensitivity and signal-to-noise ratio for molecular detection, enabling simple colorimetric assays. We quantify the performance of these strategies by introducing a figure of merit. In addition, we provide an improved understanding of the nanoplasmonic interactions that govern the optical response of core-satellite nanoassemblies. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3254756]