A cancer-associated galactosyltransferase isoenzyme.
A cancer-associated galactosyltransferase isoenzyme.
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一种与癌症相关的半乳糖基转移酶同工酶。
DOI：
10.1056/nejm197809282991306
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
A. M. Cohen
中科院分区：
文献类型：
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作者：
D. Podolsky;M. Weiser;K. Isselbacher;A. M. Cohen
半乳糖基转移酶已在人血清中进行了研究，早期报告未能证明恶性疾病中总血清半乳糖基转移酶升高。1 , 2 该实验室随后的电泳研究表明，尽管大多数血清酶在聚丙烯酰胺凝胶上以单宽峰形式运行，但癌症患者的血清标本含有第二种且电泳上不同的同工酶，称为半乳糖基转移酶同工酶 II（或GT-II).3 , 4 在本报告中，这些初步发现得到了扩展，我们提供了 387 名恶性和非恶性疾病患者的结果，证实了 GT-II 与癌症的相关性。材料和方法 患者材料 血清。 。 。
GALACTOSYLTRANSFERASE has been studied in human serum, and early reports failed to demonstrate an elevation of total serum galactosyltransferase in malignant disease.1 , 2 Subsequent electrophoretic studies from this laboratory revealed that, although the majority of the serum enzyme runs as a single broad peak on polyacrylamide gels, serum specimens from patients with cancer contain a second and electrophoretically distinct isoenzyme, referred to as galactosyltransferase isoenzyme II (or GT-II).3 , 4 In this report these initial findings are extended, and we present results on 387 patients with malignant and nonmalignant disorders, confirming the correlation of GT-II with cancer. Materials and Methods Patient Material Serum . . .