Estrogen-Mediated Gaseous Signaling Molecules in Cardiovascular Disease
Estrogen-Mediated Gaseous Signaling Molecules in Cardiovascular Disease
复制标题
心血管疾病中雌激素介导的气体信号分子
DOI：
10.1016/j.tem.2020.06.001
复制
发表时间：
2020
影响因子：
10.9
通讯作者：
Xiaodong Fu
中科院分区：
文献类型：
--
作者：
Jian-peng Teoh;Xiaosa Li;Tommaso Simoncini;Dongxing Zhu;Xiaodong Fu
性别差异被公认为心血管疾病（CVD）的一个关键危险因素。雌激素是主要的女性性激素，通过受体（ERα、ERβ或G蛋白偶联雌激素受体）启动的基因组或非基因组机制改善心血管功能。气体信号分子，包括一氧化氮（NO），硫化氢（H2S）和一氧化碳（CO），是心血管功能的重要调节剂。最近的研究表明，雌激素调节心血管细胞中这些信号分子的产生，以发挥其心血管保护作用。我们讨论了目前对心血管疾病（CVD）中气体信号分子的理解，雌激素通过调节这些分子发挥心血管保护作用的潜在机制，以及如何将这些发现转化为改善绝经后妇女的健康。
Gender difference is well recognized as a key risk factor for cardiovascular disease (CVD). Estrogen, the primary female sex hormone, improves cardiovascular functions through receptor (ERα, ERβ, or G protein-coupled estrogen receptor)-initiated genomic or non-genomic mechanisms. Gaseous signaling molecules, including nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO), are important regulators of cardiovascular function. Recent studies have demonstrated that estrogen regulates the production of these signaling molecules in cardiovascular cells to exert its cardiovascular protective effects. We discuss current understanding of gaseous signaling molecules in cardiovascular disease (CVD), the underlying mechanisms through which estrogen exerts cardiovascular protective effects by regulating these molecules, and how these findings can be translated to improve the health of postmenopausal women.