Blocking of interleukin-1 suppresses angiotensin II-induced renal injury
Blocking of interleukin-1 suppresses angiotensin II-induced renal injury
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DOI：
10.1042/cs20201406
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发表时间：
2021-09-01
期刊：
影响因子：
6
通讯作者：
Minamino, Tohru
中科院分区：
文献类型：
--
作者：
Akita, Koji;Isoda, Kikuo;Minamino, Tohru
临床高血压（HT）与肾脏炎症和促炎细胞因子循环水平升高相关。白细胞介素（IL）-1受体拮抗剂（IL-1 Ra）是最重要的抗炎细胞因子之一，在炎症反应中起重要作用。抑制IL-1可能有助于调节血管紧张素II（Ang II）诱导的HT反应。本研究旨在阐明IL-1 Ra和抗IL-1 β抗体（01 BSUR）对Ang II诱导的肾损伤的影响。为了确定IL-1 Ra对Ang II诱导的肾脏炎症的贡献，使用皮下渗透泵向雄性野生型（WT）和IL-1 Ra缺陷型（IL-1 Ra（-/-））小鼠输注Ang II（1000 ng/kg/min）14天。在输注后14天检测肾功能、组织学变化和几种mRNA表达。输注后14天，收缩压（197 +/- 5 vs 169 +/- 9 mmHg，P
Clinical hypertension (HT) is associated with renal inflammation and elevated circulating levels of proinflammatory cytokines. Interleukin (IL)-1 receptor antagonist (IL-1Ra) is one of the most important anti-inflammatory cytokines and plays a crucial role in inflammation. Inhibition of IL-1 may contribute to modulation of the Angiotensin II (Ang II)-induced HT response. The present study aimed to elucidate the effects of IL-1Ra and anti-IL-1 beta antibody (01BSUR) on Ang II-induced renal injury.To determine the contribution of IL-1Ra to Ang II-induced renal inflammation, male wildtype (WT) and IL-1Ra-deficient (IL-1Ra(-/-)) mice were infused with Ang II (1000 ng/kg/min) using subcutaneous osmotic pump for 14 days. We checked renal function, histological change, and several mRNA expressions 14 days after infusion. Fourteen days after infusion, systolic blood pressure (197 +/- 5 vs 169 +/- 9 mmHg, P