Comparison of multi-shot and single shot echo-planar diffusion tensor techniques for the optic pathway in patients with neurofibromatosis type 1.
Comparison of multi-shot and single shot echo-planar diffusion tensor techniques for the optic pathway in patients with neurofibromatosis type 1.
复制标题
多射和单射回波平面扩散张量技术对 1 型神经纤维瘤病患者视神经通路的比较。
DOI：
10.1007/s00234-019-02164-6
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发表时间：
2019
期刊：
影响因子：
2.8
通讯作者：
Shih,Chie-Schin
中科院分区：
文献类型：
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作者：
Ho,ChangY;Deardorff,Rachael;Kralik,StephenF;West,JohnD;Wu,Yu-Chien;Shih,Chie-Schin
目的弥散张量成像（DTI）可作为1型神经纤维瘤病（NF1）合并视神经胶质瘤（OG）患者治疗的标志，有助于评估视神经通路完整性。然而，在典型的单次回波平面成像（ssDTI）中，磁化率伪影是常见的。使用读数分段多镜头EPI技术（rsDTI）来减少颅底的敏感性扭曲并改善定量指标。方法纳入健康对照组、NF1无OG患儿和NF1伴OG±视觉症状患儿。所有受试者依次使用rsDTI和ssDTI序列进行扫描。计算了扩散度量和确定性光纤跟踪。呼吸道计数、体积和长度也通过双因素混合方差分析进行比较。结果正常对照5例，无OG的NF1患儿7例，有OG的NF1患儿12例。6例OG患者有视觉症状。4名受试者由于敏感性，在ssDTI上没有检测到光通路纤维，而rsDTI能够描绘出这一点。在所有受试者中，rsDTI的尿路计数（p< 0.001）、尿路体积（p< 0.001）和FA （p< 0.001）均显著高于ssDTI。rsDTI患者的MD （p< 0.001）和RD （p< 0.001）显著低于ssDTI患者。最后，在ssDTI扫描上，有视觉症状的NF1儿童与无视觉症状的NF1儿童相比，MD、AD和RD的差异显著降低。结论dti结合读数分段多镜头EPI技术可以更好地显示NF1患者的视神经通路，更可靠地测量其各向异性。与ssDTI相比，rsDTI显著增加了FA、尿路计数和体积。
PurposeDiffusion tensor imaging (DTI) may be helpful in assessing optic pathway integrity as a marker for treatment in neurofibromatosis type 1 (NF1) patients with optic gliomas (OG). However, susceptibility artifacts are common in typical single-shot echo planar imaging (ssDTI). A readout-segmented multi-shot EPI technique (rsDTI) was utilized to minimize susceptibility distortions of the skull base and improve quantitative metrics.MethodsHealthy controls, children with NF1 without OG, and NF1 with OG ± visual symptoms were included. All subjects were scanned with both rsDTI and ssDTI sequences sequentially. Diffusion metrics and deterministic fiber tracking were calculated. Tract count, volume, and length were also compared by a two-factor mixed ANOVA.ResultsFive healthy controls, 7 NF1 children without OG, and 12 NF1 children with OG were imaged. Six OG patients had visual symptoms. Four subjects had no detectable optic pathway fibers on ssDTI due to susceptibility, for which rsDTI was able to delineate. Tract count (p< 0.001), tract volume (p< 0.001), and FA (P< 0.001) were significantly higher for rsDTI versus ssDTI for all subjects. MD (p< 0.001) and RD (p< 0.001) were significantly lower for rsDTI vs ssDTI. Finally, MD, AD, and RD had a significantly lower difference in NF1 children with visual symptoms compared to NF1 children without visual symptoms only on ssDTI scans.ConclusionDTI with readout-segmented multi-shot EPI technique can better visualize the optic pathway and allow more confident measurements of anisotropy in NF1 patients. This is shown by a significant increase in FA, tract count, and volume with rsDTI versus ssDTI.