Maxillary sinus augmentation using xenogenic bone substitute material Bio-Oss® in combination with venous blood -: A histologic and histomorphometric study in humans
Maxillary sinus augmentation using xenogenic bone substitute material Bio-Oss® in combination with venous blood -: A histologic and histomorphometric study in humans
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DOI：
10.1034/j.1600-0501.2000.011003217.x
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发表时间：
2000-06-01
影响因子：
4.3
通讯作者：
Edelhoff, D
中科院分区：
文献类型：
--
作者：
Yildirim, M;Spiekermann, H;Edelhoff, D
本研究的目的是通过组织学和组织形态计量学方法评价牛骨替代材料Bio-Oss(R)联合静脉血上颌窦隆起术后的骨形成。这涉及到11例患者(平均年龄49.6岁)根据Tatum(1986)所描述的技术进行了15次鼻窦底提升手术。用牛磷灰石结合静脉血扩大窦下腔。在平均6.8个月的愈合期后，使用环钻从增大的鼻窦区进行22次骨活检。然后，38颗Branemark(R)植入物被植入骨样截骨手术和上颌骨后隆起的常规部位。根据Donath&Breuner(1982)的标准方法制作的骨活检组织切片的组织形态计量学分析显示，新生骨的平均百分比为14.7%(+/-5.0%)，残留异种骨替代材料的比例为29.7%(+/-7.8%)。Bio-Oss(R)颗粒约29.1%(+/-8.1%)的表面与新生骨直接接触。组织学上，新形成的骨变得明显，部分嵌入磷灰石颗粒，并在单独的Bio-Oss(R)颗粒之间形成小梁形式的桥梁。尽管没有破骨活性，但骨的向内生长表明异种骨移植材料吸收缓慢。当植入物被揭开时，在平均6个月的愈合期后，38个植入物中有4个已经松动。在这4个种植体中，有1个后来不得不移植，而其他的仍然是“睡眠种植体”，不包括在种植体的上部结构中。因此，假体加载前的临床存活率为89.5%。
The aim of the present study was to evaluate bone formation following maxillary sinus augmentation using bovine bone substitute material Bio-Oss(R) in combination with venous blood by means of histologic and histomorphometric examination of human biopsies. This involved a total of 15 sinus floor elevation procedures being carried out on 11 patients (average age of 49.6 years) according to the technique described by Tatum (1986). The subantral sinus cavity was augmented using bovine apatite combined with venous blood. After an average healing phase of 6.8 months, trephine burrs were used to take 22 bone biopsies from the augmented sinus region. Then 38 Branemark(R) implants were inserted in both the osteotomies resulting from bone sampling and in regular sites in the augmented posterior maxilla. Histomorphometric analysis of ground sections from the bone biopsies prepared according to the standard method of Donath & Breuner (1982) produced an average percentage of newly-formed bone of 14.7% (+/-5.0%) and a proportion of residual xenogenic bone substitute material of 29.7% (+/-7.8%). Some 29.1% (+/-8.1%) of the surface of the Bio-Oss(R) granulate was in direct contact with newly-formed bone. Histologically, newly-developed bone became evident, partly invaginating the particles of apatite and forming bridges in the form of trabeculae between the individual Bio-Oss(R) particles. Despite the absence of osteoclastic activity, the inward growth of bone indicates slow resorption of the xenogenic bone graft material. When the implants were uncovered, after an average healing phase of 6 months, 4 of the 38 implants had become loose. Of these 4 implants, 1 had to be subsequently explanted, while the others remained as "sleeping implants" and were not included in the implants superstructure. Thus, the resulting clinical survival rate, prior to prosthetic loading, was 89.5%.