Schistosome infectivity in the snail, Biomphalaria glabrata, is partially dependent on the expression of Grctm6, a Guadeloupe Resistance Complex protein.
Schistosome infectivity in the snail, Biomphalaria glabrata, is partially dependent on the expression of Grctm6, a Guadeloupe Resistance Complex protein.
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DOI：
10.1371/journal.pntd.0005362
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发表时间：
2017-02-01
影响因子：
3.8
通讯作者：
Blouin, Michael S.
中科院分区：
文献类型：
--
作者：
Allan, Euan R. O.;Tennessen, Jacob A.;Blouin, Michael S.
血吸虫病是最重要的被忽视的热带病之一。尽管有有效的化疗治疗，这种疾病继续折磨数亿人。了解寄生虫的天然中间螺宿主对抑制这种疾病至关重要。最近确定的基因组区域在加勒比海Biomphalaria光滑蜗牛强烈影响他们的抵抗力感染曼氏血吸虫。该区域包含与已知病原体识别蛋白具有结构相似性的新基因。在这里，我们阐述了这些基因之一，grctm6的可能结构和作用。我们在加勒比海蜗牛种群中表征了Grctm6的表达，并对Grctm6进行了siRNA敲低。我们发现这种蛋白质不仅在B中表达。glabrata血淋巴，但它也有调节S。曼氏尾蚴释放的感染蜗牛，使其成为一个可能的目标，为血吸虫病的生物控制。
Schistosomiasis is one of the most important neglected tropical diseases. Despite effective chemotherapeutic treatments, this disease continues to afflict hundreds of millions of people. Understanding the natural intermediate snail hosts of schistosome parasites is vital to the suppression of this disease. A recently identified genomic region in Caribbean Biomphalaria glabrata snails strongly influences their resistance to infection by Schistosoma mansoni. This region contains novel genes having structural similarity to known pathogen recognition proteins. Here we elaborate on the probable structure and role of one of these genes, grctm6. We characterised the expression of Grctm6 in a population of Caribbean snails, and performed a siRNA knockdown of Grctm6. We show that this protein is not only expressed in B. glabrata hemolymph, but that it also has a role in modulating the number of S. mansoni cercariae released by infected snails, making it a possible target for the biological control of schistosomiasis.