A truncated immunoglobulin epsilon pseudogene is found in gorilla and man but not in chimpanzee.
A truncated immunoglobulin epsilon pseudogene is found in gorilla and man but not in chimpanzee.
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在大猩猩和人类中发现了截短的免疫球蛋白ε假基因，但在黑猩猩中没有发现。
DOI：
10.1073/pnas.82.11.3712
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发表时间：
1985
影响因子：
11.1
通讯作者：
T. Honjo
中科院分区：
文献类型：
--
作者：
S. Ueda;O. Takenaka;T. Honjo
对免疫球蛋白C epsilon基因的年轻假基因进行了分子遗传学分析，为类人灵长类动物的系统发育分支模式提供了定性证据。我们发现东半球猴子有两个C epsilon基因，其中一个是经过处理的。在被研究的类人猿中，只有大猩猩和人类的基因组包含三个C epsilon基因：一个活性基因、一个截短基因和一个加工基因。到目前为止被研究的其他人种，包括黑猩猩，含有两个C epsilon基因：一个是活跃的，另一个是加工的。这些结果表明，加工过的C epsilon假基因是在东半球猴子和人科动物分化之前产生的，除非黑猩猩在该物种分化后丢失了C epsilon 2基因，否则大猩猩与人类的亲缘关系比黑猩猩更近。
Molecular genetic analyses of the young pseudogenes of the immunoglobulin C epsilon genes were carried out to obtain qualitative evidence for the phylogenetic branching pattern of hominoid primates. We found that Old World monkeys had two C epsilon genes, one of which was processed. Among the hominoids examined only the gorilla and human genomes contained three C epsilon genes: an active, a truncated, and a processed gene. Other hominoids so far examined, including chimpanzee, contained two C epsilon genes: one active and the other processed. These results suggest that the processed C epsilon pseudogene was generated before the divergence between Old World monkeys and hominoids and that the gorilla is more closely related to man than the chimpanzee is, unless the chimpanzee has lost the C epsilon 2 gene after the divergence of this species.